Journal of Chemistry (Jan 2015)

Microwave Synthesis, Characterization, and Antimicrobial Activity of Some Novel Isatin Derivatives

  • Ayman El-Faham,
  • Wael N. Hozzein,
  • Mohammad A. M. Wadaan,
  • Sherine N. Khattab,
  • Hazem A. Ghabbour,
  • Hoong-Kun Fun,
  • Mohammed Rafiq Siddiqui

DOI
https://doi.org/10.1155/2015/716987
Journal volume & issue
Vol. 2015

Abstract

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Three series of isatin derivatives [3-hydrazino, 3-thiosemicarbazino, and 3-imino carboxylic acid derivatives] were synthesized employing microwave irradiation. The prepared compounds were characterized by FT-IR, NMR, elemental analysis, and X-ray crystallography for derivatives 5b. The synthesized compounds were screened for antimicrobial activity against selected bacteria and fungi. The results revealed that the N-alkyl isatin derivatives were biologically active with different spectrums activity. Most of the 3-hydrazino and 3-thiosemicarbazino isatin derivatives were biologically inactive and generally the active derivatives showed weak to moderate activity mainly against Gram-positive bacteria. The imino isatin carboxylic acid derivatives (2-[4-(1-benzyl-5-bromo-2-oxoindolin-3-ylideneamino) phenyl]acetic acid, 5d) showed promising activity against all tested Gram-positive bacteria and against fungal pathogens.