The role of Nrf2 in the secondary brain injury after intracerebral hemorrhage

Abstract

Currently, there is still a lack of effective treatment options for intracerebral hemorrhage (ICH). It remains crucial to explore treatment to alleviate the secondary brain injury after ICH and improve the prognosis. Nuclear factor ⁃erythroid 2⁃related factor 2 (Nrf2) is the key transcriptional factor during oxidative stress. It also plays an important role in the secondary injury after ICH. This article reviews the regulatory mechanism of Nrf2 and its protective role in the secondary brain injury after ICH, to explore its possibility as a therapentic target.

Keywords

• nuclear factor ⁃ erythroid 2 ⁃ related factor 2 (not in mesh)
• cerebral hemorrhage
• brain injuries
• oxidative stress
• reveiw