Water-dispersible PEG-curcumin/amine-functionalized covalent organic framework nanocomposites as smart carriers for in vivo drug delivery

Guiyang Zhang; Xinle Li; Qiaobo Liao; Yanfeng Liu; Kai Xi; Wenyu Huang; Xudong Jia

doi:10.1038/s41467-018-04910-5

Nature Communications (Jul 2018)

Water-dispersible PEG-curcumin/amine-functionalized covalent organic framework nanocomposites as smart carriers for in vivo drug delivery

Guiyang Zhang,
Xinle Li,
Qiaobo Liao,
Yanfeng Liu,
Kai Xi,
Wenyu Huang,
Xudong Jia

Affiliations

Guiyang Zhang: School of Chemistry and Chemical Engineering, Nanjing University
Xinle Li: Department of Chemistry, Iowa State University
Qiaobo Liao: School of Chemistry and Chemical Engineering, Nanjing University
Yanfeng Liu: School of Chemistry and Chemical Engineering, Nanjing University
Kai Xi: School of Chemistry and Chemical Engineering, Nanjing University
Wenyu Huang: Department of Chemistry, Iowa State University
Xudong Jia: School of Chemistry and Chemical Engineering, Nanjing University

DOI: https://doi.org/10.1038/s41467-018-04910-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Despite their potential application as drug-delivery carriers, covalent organic frameworks (COF) have been only evaluated in vitro. Here the authors show by real time tracking in vivo the cell uptake of anticancer-drug loaded and water dispersible COFs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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