Anti-<i>Mycobacterium tuberculosis</i> Terpenoids from <i>Resina Commiphora</i>
Chuan-Zhi Zhu,
Bin-Yuan Hu,
Jia-Wang Liu,
Yi Cai,
Xin-Chun Chen,
Da-Peng Qin,
Yong-Xian Cheng,
Zong-De Zhang
Affiliations
Chuan-Zhi Zhu
Laboratory of Molecular Biology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
Bin-Yuan Hu
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China
Jia-Wang Liu
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China
Yi Cai
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China
Xin-Chun Chen
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China
Da-Peng Qin
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China
Yong-Xian Cheng
Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, School of Basic Medicine, Shenzhen University Health Science Center, Shenzhen 518060, China
Zong-De Zhang
Laboratory of Molecular Biology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China
Four new compounds including two new sesquiterpenoid dimers, commiphoroids E (1) and F (2), a new triterpenoid (3), and a new sesquiterpenoid (4), along with three known terpenoids (5−7) were isolated from Resina Commiphora, whose structures were identified by NMR spectra, HRESIMS, and X-ray diffraction analysis. Compounds 1 and 2 both bear an O-bridge ring and feature a plausible [4 + 2] Diels–Alder cycloaddition reaction. Antimycobacterial activities show that all the tested compounds (200 μM) could inhibit the growth of both sensitive and clinically multi-drug resistant (MDR) isolated strains. In addition, cellular toxicity of the isolates against human cancer cells and THP-1 monocyte cells was examined.
