Criteria of endogenous intoxication in patients with atherothrombotic ischemic stroke and cardioembolic ischemic stroke

Abstract

To determine the concentration of IgG, the level of middle mass molecules and oligopeptides in blood plasma of patients with atherothrombotic and cardioembolic ischemic stroke. The study involved 122 patients diagnosed with atherothrombotic and cardioembolic ischemic stroke and 40 relatively healthy donors. The concentration of IgG was determined by affinity chromatography on protein A sepharose. The level of oligopeptides and middle mass molecules were determined by methods described by Nikolaichyk V. and co-authors. IgG concentration increased with the development of cardioembolic ischemic stroke, reaching 10,7±0,97 mg/ml on the 14th day, while on admission to hospital was 5,0±0,35 mg/ml. For atherothrombotic ischemic stroke the level of middle mass molecules in the plasma was 3.35 times higher, while the level of oligopeptides was 3.6 times higher relative to donors. Cardioembolic ischemic stroke was accompanied by 2.6 times higher level of middle mass molecules and by 2.5 times higher level of oligopeptides relative to donors. Cardioembolic ischemic stroke was accompanied by 2 times higher concentration of IgG in plasma on the 14th day of desease relative to the rate specified on admission to hospital. For both subtypes of ischemic stroke an increase in middle mass molecules and oligopeptides was observed, indicating the activation of proteolytic processes in the organism.

Keywords

• atherothrombotic ischemic stroke, cardioembolic ischemic stroke, IgG, middle mass molecules