Кардиоваскулярная терапия и профилактика (Jun 2015)
ARTERIAL WALL STIFFNESS INDICES IN YOUNG PERSONS WITH FAMILY PREDISPOSITION TO ARTERIAL HYPERTENSION
Abstract
Aim. To study the specifics of vessel wall remodeling in arteries of young persons with family history (FH) of arterial hypertension (AH). Material and methods. Totally 95 persons assessed, parents of whom had AH. During the study we selected them into 2 groups: with higher normal and normal BP Controls were healthy persons with FH of AH. All underwent ambulatory blood pressure monitoring (ABPM), ultrasound examination (USE) of carotid arteries, the coefficient of transverse elasticity was measured, elasticity coefficient in transverse section, Jung elasticity module, stiffness index, pulse wave velocity (PWV), integral module of arterial system resilience for the vessels of muscular and elastic type. Results. The significant changes of elasticity were revealed for the vessels, as the increase of PWV and integral module of resilience of the muscular and elastic wall. These were found in patients with higher normal BP having FH of AH. In patients with higher normal BP these parameters did not differ significantly. In USE of carotid arteries in the group of normalBP persons and with FH of AH family anamnesis there was significant increase of the stiffness index of vessel wall (p<0,005), transverse elasticity coefficient (p=0,0001) and Jung elasticity module (p<0,005). Conclusion. In younger persons with FH of AH the changes of PWV were depended on BP level, and the values of common carotid arteries elasticity (as the coefficient of transverse distension, stiffness index, Jung elasticity index) marked earlier processes of vessel wall remodeling in normal BP, that can be used as screening tool for diagnostics of arterial rigidity onset and prognosis of cardiovascular diseases in younger persons having the relatives of the first line with AH.
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