Case report: Cardiac intimal sarcoma in a young child

Sanne Verbeek; Raf Sciot; Maria Debiec-Rychter; Veerle Labarque; Bart Meyns; Bjorn Cools

doi:10.3389/fped.2023.1238847

Frontiers in Pediatrics (Sep 2023)

Case report: Cardiac intimal sarcoma in a young child

Sanne Verbeek,
Raf Sciot,
Maria Debiec-Rychter,
Veerle Labarque,
Bart Meyns,
Bjorn Cools

Affiliations

Sanne Verbeek: Department of Pathology, University Hospitals Leuven, Leuven, Belgium
Raf Sciot: Department of Pathology, University Hospitals Leuven, Leuven, Belgium
Maria Debiec-Rychter: Center for Human Genetics, Catholic University Leuven, Leuven, Belgium
Veerle Labarque: Department of Pediatric Hematology and Oncology, University Hospitals Leuven, Leuven, Belgium
Bart Meyns: Department of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium
Bjorn Cools: Department of Pediatric and Congenital Cardiology, University Hospitals Leuven, Leuven, Belgium

DOI: https://doi.org/10.3389/fped.2023.1238847
Journal volume & issue: Vol. 11

Abstract

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Undifferentiated mesenchymal tumors from the intimal layer (intimal sarcomas) are rare within the ventricles and exceptional in children. A rare case of an intimal sarcoma located in the right ventricle in a young child is presented with need for urgent surgical resection due to mechanical flow obstruction. Tumor cells showed amplification of MDM2 gene and a homozygous loss of CDKN2A on 9p21. A review of the literature regarding primary cardiac malignancies and intimal sarcoma in children is provided.

Published in Frontiers in Pediatrics

ISSN: 2296-2360 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Pediatrics
Website: http://journal.frontiersin.org/journal/pediatrics

About the journal

Abstract

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