Communications Biology (Mar 2021)

Brain pathology recapitulates physiology: A network meta-analysis

  • Thomas J. Vanasse,
  • Peter T. Fox,
  • P. Mickle Fox,
  • Franco Cauda,
  • Tommaso Costa,
  • Stephen M. Smith,
  • Simon B. Eickhoff,
  • Jack L. Lancaster

DOI
https://doi.org/10.1038/s42003-021-01832-9
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 11

Abstract

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Peter Fox & Thomas Vanasse et al. compare atrophy patterns in 40+ brain disorders with healthy task-activation networks across 100+ behavioral domains. Their analyses demonstrate strong spatial correspondence between disease-related structural coalterations and functional networks, an observation that greatly extends the scope of the network-degeneration hypothesis. Further, the metabolic cost of network hubs (nodal stress) is implicated as a common mechanism across a wide range of brain disorders.