The First Case of <i>Granulicatella adiacens</i> Identified from a Resected Heart Valve by Next Generation Sequencing (NGS) in Poland
Anna Podgórska,
Maria Kordybach-Prokopiuk,
Maria Jaworska-Wilczyńska,
Piotr Hoffman,
Katarzyna Biernacka,
Krzysztof Kuśmierski,
Robert Kuthan,
Tomasz Hryniewiecki,
Anna Lutyńska
Affiliations
Anna Podgórska
Department of Medical Biology, National Institute of Cardiology, Stefan Cardinal Wyszyński State Research Institute, 42 Alpejska Street, 04-628 Warsaw, Poland
Maria Kordybach-Prokopiuk
Department of Congenital Heart Diseases, National Institute of Cardiology, Stefan Cardinal Wyszyński State Research Institute, 42 Alpejska Street, 04-628 Warsaw, Poland
Maria Jaworska-Wilczyńska
Department of Valvular Heart Disease, National Institute of Cardiology, Stefan Cardinal Wyszyński State Research Institute, 42 Alpejska Street, 04-628 Warsaw, Poland
Piotr Hoffman
Department of Congenital Heart Diseases, National Institute of Cardiology, Stefan Cardinal Wyszyński State Research Institute, 42 Alpejska Street, 04-628 Warsaw, Poland
Katarzyna Biernacka
Department of Congenital Heart Diseases, National Institute of Cardiology, Stefan Cardinal Wyszyński State Research Institute, 42 Alpejska Street, 04-628 Warsaw, Poland
Krzysztof Kuśmierski
Department of Cardiac Surgery and Transplantology, National Institute of Cardiology, Stefan Cardinal Wyszyński State Research Institute, 42 Alpejska Street, 04-628 Warsaw, Poland
Robert Kuthan
Department of Medical Microbiology, Medical University of Warsaw, 5 Chałubińskiego Street, 02-004 Warsaw, Poland
Tomasz Hryniewiecki
Department of Valvular Heart Disease, National Institute of Cardiology, Stefan Cardinal Wyszyński State Research Institute, 42 Alpejska Street, 04-628 Warsaw, Poland
Anna Lutyńska
Department of Medical Biology, National Institute of Cardiology, Stefan Cardinal Wyszyński State Research Institute, 42 Alpejska Street, 04-628 Warsaw, Poland
In this report, we describe the course and successful treatment of a case of complicated infective endocarditis (IE). A patient presented with a high-grade, irregular fever with chills lasting at least 2 months along with dyspnoea, chest pain, fatigue, weight loss, and night sweats during the previous 3 months. As well as cardiac congenital disorders, he was found to have Granulicatella adiacens infective aortic valve endocarditis, presumably transmitted from the oral cavity niche. Validated metagenomic 16S rDNA next generation sequencing was used to perform taxonomic identification, allowing for specific adequate antibiotic therapy instead of empiric therapy. This paper highlights the critical role of rapid taxonomic identification of nutritionally variant streptococci and the benefit of proper IE treatment in avoiding relapses or fatal complications.
