Nature Communications (Nov 2022)

A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation

  • Jianfeng Wu,
  • Kang Yang,
  • Shaowei Cai,
  • Xiaohan Zhang,
  • Lichen Hu,
  • Fanjia Lin,
  • Su-qin Wu,
  • Changchun Xiao,
  • Wen-Hsien Liu,
  • Jiahuai Han

DOI
https://doi.org/10.1038/s41467-022-34969-0
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 20

Abstract

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Plasma cells are terminally differentiated B cells that are specialized for antibody secretion. Authors show here that genomic deletion of the p38α mitogen activated protein kinase specifically in the B cell lineage leads to diminished plasma cell differentiation via impairment of a transcriptional regulatory program by BLIMP1.