Nature Communications (Oct 2020)
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
- David Olagnier,
- Ensieh Farahani,
- Jacob Thyrsted,
- Julia Blay-Cadanet,
- Angela Herengt,
- Manja Idorn,
- Alon Hait,
- Bruno Hernaez,
- Alice Knudsen,
- Marie Beck Iversen,
- Mirjam Schilling,
- Sofie E. Jørgensen,
- Michelle Thomsen,
- Line S. Reinert,
- Michael Lappe,
- Huy-Dung Hoang,
- Victoria H. Gilchrist,
- Anne Louise Hansen,
- Rasmus Ottosen,
- Camilla G. Nielsen,
- Charlotte Møller,
- Demi van der Horst,
- Suraj Peri,
- Siddharth Balachandran,
- Jinrong Huang,
- Martin Jakobsen,
- Esben B. Svenningsen,
- Thomas B. Poulsen,
- Lydia Bartsch,
- Anne L. Thielke,
- Yonglun Luo,
- Tommy Alain,
- Jan Rehwinkel,
- Antonio Alcamí,
- John Hiscott,
- Trine H. Mogensen,
- Søren R. Paludan,
- Christian K. Holm
Affiliations
- David Olagnier
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Ensieh Farahani
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Jacob Thyrsted
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Julia Blay-Cadanet
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Angela Herengt
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Manja Idorn
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Alon Hait
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Bruno Hernaez
- Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas - Universidad Autónoma de Madrid)
- Alice Knudsen
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Marie Beck Iversen
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Mirjam Schilling
- Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
- Sofie E. Jørgensen
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Michelle Thomsen
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Line S. Reinert
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Michael Lappe
- Omiics ApS
- Huy-Dung Hoang
- Children’s Hospital of Eastern Ontario Research Institute, Department of Biochemistry Microbiology and Immunology, University of Ottawa
- Victoria H. Gilchrist
- Children’s Hospital of Eastern Ontario Research Institute, Department of Biochemistry Microbiology and Immunology, University of Ottawa
- Anne Louise Hansen
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Rasmus Ottosen
- Department of Chemistry, Aarhus University
- Camilla G. Nielsen
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Charlotte Møller
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Demi van der Horst
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Suraj Peri
- Fox Chase Cancer Center
- Siddharth Balachandran
- Fox Chase Cancer Center
- Jinrong Huang
- Lars Bolund Institute of Regenerative Medicine, BGI-Shenzhen
- Martin Jakobsen
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Esben B. Svenningsen
- Department of Chemistry, Aarhus University
- Thomas B. Poulsen
- Department of Chemistry, Aarhus University
- Lydia Bartsch
- Department of Pediatrics and Adolescent Medicine, Division of Pediatric Neurology, University Medical Center Göttingen
- Anne L. Thielke
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Yonglun Luo
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Tommy Alain
- Children’s Hospital of Eastern Ontario Research Institute, Department of Biochemistry Microbiology and Immunology, University of Ottawa
- Jan Rehwinkel
- Medical Research Council Human Immunology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford
- Antonio Alcamí
- Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas - Universidad Autónoma de Madrid)
- John Hiscott
- Istituto Pasteur Italia-Cenci Bolognetti Foundation
- Trine H. Mogensen
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Søren R. Paludan
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- Christian K. Holm
- Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University
- DOI
- https://doi.org/10.1038/s41467-020-18764-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Viral infections usually cause disease through direct cytopathogenic effects and excessive inflammatory responses. Here, Olagnier et al. show that two NRF2 agonists, 4-OI and DMF, possess broad IFN-independent antiviral activity and decrease host inflammatory response to SARS-CoV-2 infection.
