Nature Communications (Jan 2016)

E2F function in muscle growth is necessary and sufficient for viability in Drosophila

  • Maria Paula Zappia,
  • Maxim V. Frolov

DOI
https://doi.org/10.1038/ncomms10509
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 16

Abstract

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The transcriptional regulators E2F/Dp play a critical role in cell-cycle regulation, but it is unclear why E2F-deficient flies die. Here, the authors show this is linked to the function of E2F in adult Drosophilaskeletal muscle, with the contribution of E2f1 being most important in post-fusion muscle.