Frontiers in Neuroscience (Dec 2022)
Inhibition by rno-circRNA-013017 of the apoptosis of motor neurons in anterior horn and descending axonal degeneration in rats after traumatic spinal cord injury
- Chuan Qin,
- Chuan Qin,
- Chuan Qin,
- Chuan Qin,
- Chuan Qin,
- Chuan Qin,
- Yi Liu,
- Yi Liu,
- Yi Liu,
- Yi Liu,
- Yi Liu,
- Pei-Pei Xu,
- Pei-Pei Xu,
- Pei-Pei Xu,
- Pei-Pei Xu,
- Pei-Pei Xu,
- Xin Zhang,
- Xin Zhang,
- Xin Zhang,
- Xin Zhang,
- Xin Zhang,
- Zuliyaer Talifu,
- Zuliyaer Talifu,
- Zuliyaer Talifu,
- Zuliyaer Talifu,
- Zuliyaer Talifu,
- Jia-Yi Liu,
- Jia-Yi Liu,
- Jia-Yi Liu,
- Jia-Yi Liu,
- Jia-Yi Liu,
- Ying-Li Jing,
- Ying-Li Jing,
- Ying-Li Jing,
- Fan Bai,
- Fan Bai,
- Fan Bai,
- Li-Xi Zhao,
- Li-Xi Zhao,
- Li-Xi Zhao,
- Yan Yu,
- Yan Yu,
- Yan Yu,
- Feng Gao,
- Feng Gao,
- Feng Gao,
- Feng Gao,
- Feng Gao,
- Jian-Jun Li,
- Jian-Jun Li,
- Jian-Jun Li,
- Jian-Jun Li,
- Jian-Jun Li
Affiliations
- Chuan Qin
- Department of Urology, Beijing Friendship Hospital, Beijing, China
- Chuan Qin
- School of Rehabilitation Medicine, Capital Medical University, Beijing, China
- Chuan Qin
- China Rehabilitation Science Institute, Beijing, China
- Chuan Qin
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Chuan Qin
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Chuan Qin
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Yi Liu
- School of Rehabilitation Medicine, Capital Medical University, Beijing, China
- Yi Liu
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Yi Liu
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Yi Liu
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Yi Liu
- Department of Rehabilitation Medicine, The Second Hospital of Anhui Medical University, Hefei, China
- Pei-Pei Xu
- School of Rehabilitation Medicine, Capital Medical University, Beijing, China
- Pei-Pei Xu
- China Rehabilitation Science Institute, Beijing, China
- Pei-Pei Xu
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Pei-Pei Xu
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Pei-Pei Xu
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Xin Zhang
- School of Rehabilitation Medicine, Capital Medical University, Beijing, China
- Xin Zhang
- China Rehabilitation Science Institute, Beijing, China
- Xin Zhang
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Xin Zhang
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Xin Zhang
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Zuliyaer Talifu
- School of Rehabilitation Medicine, Capital Medical University, Beijing, China
- Zuliyaer Talifu
- China Rehabilitation Science Institute, Beijing, China
- Zuliyaer Talifu
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Zuliyaer Talifu
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Zuliyaer Talifu
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Jia-Yi Liu
- School of Rehabilitation Medicine, Capital Medical University, Beijing, China
- Jia-Yi Liu
- China Rehabilitation Science Institute, Beijing, China
- Jia-Yi Liu
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Jia-Yi Liu
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Jia-Yi Liu
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Ying-Li Jing
- China Rehabilitation Science Institute, Beijing, China
- Ying-Li Jing
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Ying-Li Jing
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Fan Bai
- China Rehabilitation Science Institute, Beijing, China
- Fan Bai
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Fan Bai
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Li-Xi Zhao
- China Rehabilitation Science Institute, Beijing, China
- Li-Xi Zhao
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Li-Xi Zhao
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Yan Yu
- China Rehabilitation Science Institute, Beijing, China
- Yan Yu
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Yan Yu
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Feng Gao
- School of Rehabilitation Medicine, Capital Medical University, Beijing, China
- Feng Gao
- China Rehabilitation Science Institute, Beijing, China
- Feng Gao
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Feng Gao
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Feng Gao
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- Jian-Jun Li
- School of Rehabilitation Medicine, Capital Medical University, Beijing, China
- Jian-Jun Li
- China Rehabilitation Science Institute, Beijing, China
- Jian-Jun Li
- Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China
- Jian-Jun Li
- Department of Spinal and Neural Functional Reconstruction, China Rehabilitation Research Center, Beijing, China
- Jian-Jun Li
- Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China
- DOI
- https://doi.org/10.3389/fnins.2022.1065897
- Journal volume & issue
-
Vol. 16
Abstract
IntroductionSpinal cord injury (SCI) often causes continuous neurological damage to clinical patients. Circular RNAs (circRNAs) are related to a lot of diseases, including SCI. We previously found five candidate circRNAs which were likely to regulate the secondary pathophysiological changes in rat model after traumatic SCI.MethodsIn this study, we first selected and overexpressed target circRNA in rats. We then explored its functional roles using various functional assays in a rat model after SCI.ResultsWe found that rno-circRNA-013017—the selected target circRNA—reduced neuron apoptosis, preserved the survival and activity of motor neurons, and regulated apoptosis-related proteins at 3 days post-SCI using western blot, immunofluorescence and polymerase chain reaction. Additionally, we found that rno-circRNA-013017 inhibited descending axonal degeneration and preserved motor neurons and descending axons at 6 weeks post-SCI using immunofluorescence, biotin dextran amine diffusion tensor imaging. Finally, the overexpression of rno-circRNA-013017 promoted the locomotor function of rats after SCI using open-field test and gait analysis.ConclusionFocusing on the functions of rno-circRNA-013017, this study provides new options for future studies exploring therapeutic targets and molecular mechanisms for SCI.
Keywords