Nature Communications (May 2020)

Intracellular Staphylococcus aureus persisters upon antibiotic exposure

  • Frédéric Peyrusson,
  • Hugo Varet,
  • Tiep Khac Nguyen,
  • Rachel Legendre,
  • Odile Sismeiro,
  • Jean-Yves Coppée,
  • Christiane Wolz,
  • Tanel Tenson,
  • Françoise Van Bambeke

DOI
https://doi.org/10.1038/s41467-020-15966-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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Bacterial persister cells exhibit a transient non-growing state and antibiotic tolerance. Here, Peyrusson et al. provide evidence of metabolically active Staphylococcus aureus persisters within infected host cells exposed to antibiotics and analyse transcriptomic alterations associated with persistence.