Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2

Nuria Cerdá-Esteban; Heike Naumann; Silvia Ruzittu; Nancy Mah; Igor M. Pongrac; Corinna Cozzitorto; Angela Hommel; Miguel A. Andrade-Navarro; Ezio Bonifacio; Francesca M. Spagnoli

doi:10.1038/ncomms14127

Nature Communications (Feb 2017)

Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2

Nuria Cerdá-Esteban,
Heike Naumann,
Silvia Ruzittu,
Nancy Mah,
Igor M. Pongrac,
Corinna Cozzitorto,
Angela Hommel,
Miguel A. Andrade-Navarro,
Ezio Bonifacio,
Francesca M. Spagnoli

Affiliations

Nuria Cerdá-Esteban: Laboratory of Molecular and Cellular Basis of Embryonic Development, Max Delbrück Center for Molecular Medicine
Heike Naumann: Laboratory of Molecular and Cellular Basis of Embryonic Development, Max Delbrück Center for Molecular Medicine
Silvia Ruzittu: Laboratory of Molecular and Cellular Basis of Embryonic Development, Max Delbrück Center for Molecular Medicine
Nancy Mah: Computational Biology and Data Mining, Max Delbrück Center for Molecular Medicine
Igor M. Pongrac: Laboratory of Molecular and Cellular Basis of Embryonic Development, Max Delbrück Center for Molecular Medicine
Corinna Cozzitorto: Laboratory of Molecular and Cellular Basis of Embryonic Development, Max Delbrück Center for Molecular Medicine
Angela Hommel: DFG-Center for Regenerative Therapies Dresden, Technische Universität Dresden
Miguel A. Andrade-Navarro: Computational Biology and Data Mining, Max Delbrück Center for Molecular Medicine
Ezio Bonifacio: DFG-Center for Regenerative Therapies Dresden, Technische Universität Dresden
Francesca M. Spagnoli: Laboratory of Molecular and Cellular Basis of Embryonic Development, Max Delbrück Center for Molecular Medicine

DOI: https://doi.org/10.1038/ncomms14127
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 13

Abstract

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Liver and pancreas cells arise from a common endoderm progenitor in the embryo, but what regulates their cell fate is unclear. Here, the authors show that expression of the Three-Amino-acid-Loop-Extension (TALE) homeobox TG-interacting factor 2 (TGIF2) in hepatocytes reprogrammes the cells to a pancreatic fate.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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