Adverse Pregnancy Outcomes by Degree of Maternal Serum Analyte Elevation: A Retrospective Cohort Study

Amanda Yeaton-Massey; Rebecca J. Baer; Larry Rand; Laura L. Jelliffe-Pawlowski; Deirdre J. Lyell

doi:10.1055/s-0040-1716741

American Journal of Perinatology Reports (Oct 2020)

Adverse Pregnancy Outcomes by Degree of Maternal Serum Analyte Elevation: A Retrospective Cohort Study

Amanda Yeaton-Massey,
Rebecca J. Baer,
Larry Rand,
Laura L. Jelliffe-Pawlowski,
Deirdre J. Lyell

Affiliations

Amanda Yeaton-Massey: Department of Obstetrics and Gynecology, Stanford University, Stanford, California
Rebecca J. Baer: Department of Pediatrics, University of California San Diego, La Jolla, California
Larry Rand: California Preterm Birth Initiative, University of California San Francisco, San Francisco, California
Laura L. Jelliffe-Pawlowski: California Preterm Birth Initiative, University of California San Francisco, San Francisco, California
Deirdre J. Lyell: Department of Obstetrics and Gynecology, Stanford University, Stanford, California

DOI: https://doi.org/10.1055/s-0040-1716741
Journal volume & issue: Vol. 10, no. 04
pp. e369 – e379

Abstract

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Objective The aim of this study was to evaluate rates of preterm birth (PTB) and obstetric complication with maternal serum analytes > 2.5 multiples of the median (MoM) by degree of elevation. Study Design Retrospective cohort study of singleton live-births participating in the California Prenatal Screening Program (2005–2011) examining PTB and obstetric complication for α-fetoprotein (AFP), human chorionic gonadotropin (hCG), unconjugated estriol (uE3), and inhibin A (INH) by analyte subgroup (2.5 to 2.5 MoM confer an increased risk of PTB and, except for uE3, obstetric complication, and risks for each are not uniformly linear. These data can help guide patient counseling and antenatal management.

Published in American Journal of Perinatology Reports

ISSN: 2157-6998 (Print); 2157-7005 (Online)
Publisher: Thieme Medical Publishers, Inc.
Country of publisher: United States
LCC subjects: Medicine: Gynecology and obstetrics
Website: https://doi.org/10.1055/s-00000169

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Abstract

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