Mechanism of microtubule stabilization by taccalonolide AJ

Yuxi Wang; Yamei Yu; Guo-Bo Li; Shu-Ang Li; Chengyong Wu; Benoît Gigant; Wenming Qin; Hao Chen; Yangping Wu; Qiang Chen; Jinliang Yang

doi:10.1038/ncomms15787

Nature Communications (Jun 2017)

Mechanism of microtubule stabilization by taccalonolide AJ

Yuxi Wang,
Yamei Yu,
Guo-Bo Li,
Shu-Ang Li,
Chengyong Wu,
Benoît Gigant,
Wenming Qin,
Hao Chen,
Yangping Wu,
Qiang Chen,
Jinliang Yang

Affiliations

Yuxi Wang: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy
Yamei Yu: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy
Guo-Bo Li: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy
Shu-Ang Li: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy
Chengyong Wu: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy
Benoît Gigant: Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay
Wenming Qin: National Center for Protein Science Shanghai, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Hao Chen: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy
Yangping Wu: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy
Qiang Chen: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy
Jinliang Yang: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy

DOI: https://doi.org/10.1038/ncomms15787
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 8

Abstract

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Microtubule-stabilizing agents (MSAs) promote the polymerization of tubulin and are of great interest as anticancer drugs. Here the authors present the crystal structure of the MSA taccalonolide AJ bound to tubulin and give insights into its mode of action, which might help in the design of novel MSAs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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