Inhibition of VMAT2 by β2-adrenergic agonists, antagonists, and the atypical antipsychotic ziprasidone

Abstract

Several existing β2-adrenergic agonists and antagonists, as well as the atypical antipsychotic ziprasidone, are identified as high affinity VMAT2 inhibitors, which could have implications for drug repurposing and drug derivatization campaigns.