Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy

Liangrong Shi; Junjun Wang; Nianhua Ding; Yi Zhang; Yibei Zhu; Shunli Dong; Xiaohui Wang; Changli Peng; Chunhui Zhou; Ledu Zhou; Xiaodong Li; Hongbing Shi; Wei Wu; Xueyin Long; Changping Wu; Weihua Liao

doi:10.1038/s41467-019-13204-3

Nature Communications (Nov 2019)

Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy

Liangrong Shi,
Junjun Wang,
Nianhua Ding,
Yi Zhang,
Yibei Zhu,
Shunli Dong,
Xiaohui Wang,
Changli Peng,
Chunhui Zhou,
Ledu Zhou,
Xiaodong Li,
Hongbing Shi,
Wei Wu,
Xueyin Long,
Changping Wu,
Weihua Liao

Affiliations

Liangrong Shi: Radiological Intervention Center, Department of Radiology, Xiangya Hospital, Central South University
Junjun Wang: Department of Oncology, the Third Affiliated Hospital, Soochow University
Nianhua Ding: Radiological Intervention Center, Department of Radiology, Xiangya Hospital, Central South University
Yi Zhang: Dept. of Pharmacology, College of Pharmaceutical Sciences, Soochow University
Yibei Zhu: Institute of Biotechnology, Key Laboratory of Clinical Immunology of Jiangsu Province, Soochow University
Shunli Dong: Dept. of Pharmacology, College of Pharmaceutical Sciences, Soochow University
Xiaohui Wang: Dept. of Pharmacology, College of Pharmaceutical Sciences, Soochow University
Changli Peng: Radiological Intervention Center, Department of Radiology, Xiangya Hospital, Central South University
Chunhui Zhou: Radiological Intervention Center, Department of Radiology, Xiangya Hospital, Central South University
Ledu Zhou: Department of General Surgery, Xiangya Hospital, Central South University
Xiaodong Li: Department of Oncology, the Third Affiliated Hospital, Soochow University
Hongbing Shi: Department of Oncology, the Third Affiliated Hospital, Soochow University
Wei Wu: National Clinical Research Center for Geriatric Disorder, Xiangya Hospital, Central South University
Xueyin Long: Radiological Intervention Center, Department of Radiology, Xiangya Hospital, Central South University
Changping Wu: Department of Oncology, the Third Affiliated Hospital, Soochow University
Weihua Liao: Radiological Intervention Center, Department of Radiology, Xiangya Hospital, Central South University

DOI: https://doi.org/10.1038/s41467-019-13204-3
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Radiofrequency ablation is used to treat metastatic colorectal cancer. In this study, the authors show that incomplete ablation of tumours results in metastases and show in mouse models that the chemokine CCL2 recruits myeloid cells to the partially ablated tumours, which can block T cell function.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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