The COMET toolkit for composing customizable genetic programs in mammalian cells

Patrick S. Donahue; Joseph W. Draut; Joseph J. Muldoon; Hailey I. Edelstein; Neda Bagheri; Joshua N. Leonard

doi:10.1038/s41467-019-14147-5

Nature Communications (Feb 2020)

The COMET toolkit for composing customizable genetic programs in mammalian cells

Patrick S. Donahue,
Joseph W. Draut,
Joseph J. Muldoon,
Hailey I. Edelstein,
Neda Bagheri,
Joshua N. Leonard

Affiliations

Patrick S. Donahue: Department of Chemical and Biological Engineering, Northwestern University
Joseph W. Draut: Department of Chemical and Biological Engineering, Northwestern University
Joseph J. Muldoon: Department of Chemical and Biological Engineering, Northwestern University
Hailey I. Edelstein: Department of Chemical and Biological Engineering, Northwestern University
Neda Bagheri: Department of Chemical and Biological Engineering, Northwestern University
Joshua N. Leonard: Department of Chemical and Biological Engineering, Northwestern University

DOI: https://doi.org/10.1038/s41467-019-14147-5
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 19

Abstract

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Engineering mammalian cellular functions requires a toolkit of orthogonal and well-characterized genetic components. Here the authors develop COMET: an ensemble of transcription factors, promoters, and accompanying models for the design and construction of genetic programs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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