The current understanding of precision medicine and personalised medicine in selected research disciplines: study protocol of a systematic concept analysis
Emma Matthews,
Adam Henschke,
Christine Phillips,
Matthew Cook,
Anne Parkinson,
Ellen Brown,
Karen Brown,
Christopher J Nolan,
Christian Lueck,
Hanna Suominen,
Jane Desborough,
Nicola Brew-Sam,
Lachlan Pedley,
Harry Ebbeck,
Kristine Wright,
Anne Bruestle,
Katrina Chisholm,
Simone Collins,
Eleni Daskalaki,
Janet Drew,
Mark Elisha,
Vanessa Fanning,
Jessica Herron,
Krishnan Murugappan,
Dragomir Neshev,
Antonio Tricoli
Affiliations
Emma Matthews
1 Queen Square Centre for Neuromuscular Diseases, Institute of Neurology, University College London, London, UK
Adam Henschke
1 National Security College, Australian National University, Canberra, Australia
Christine Phillips
Medical School, Australian National University, Canberra, Australian Capital Territory, Australia
Matthew Cook
The John Curtin School of Medical Research, College of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, Australia
Anne Parkinson
1 Sue Ryder Leckhampton Court Hospice, Cheltenham, Gloucestershire, UK
Ellen Brown
Department of Health Services Research and Policy, Australian National University, Canberra, Australian Capital Territory, Australia
Karen Brown
Department of Health Services Research and Policy, Australian National University, Canberra, Australian Capital Territory, Australia
Christopher J Nolan
Department of Endocrinology, The Canberra Hospital, Canberra, Australian Capital Territory, Australia
Christian Lueck
1Department of Neurology, The Canberra Hospital, Canberra, Australian Capital Territory, Australia
Hanna Suominen
1Research School of Computer Science, The Australian National University, Canberra, ACT, Australia
Jane Desborough
Department of Health Services Research and Policy, Australian National University, Canberra, Australian Capital Territory, Australia
Nicola Brew-Sam
Department of Health Services Research and Policy, Australian National University, Canberra, Australian Capital Territory, Australia
Lachlan Pedley
Department of Health Services Research and Policy, Australian National University, Canberra, Australian Capital Territory, Australia
Harry Ebbeck
Department of Health Services Research and Policy, Australian National University, Canberra, Australian Capital Territory, Australia
Kristine Wright
Department of Health Services Research and Policy, Australian National University, Canberra, Australian Capital Territory, Australia
Anne Bruestle
5 The John Curtin School of Medical Research, College of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, Australia
Katrina Chisholm
1 National Centre for Epidemiology and Population Health, College of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, Australia
Simone Collins
4 The Centenary Hospital for Women and Children, Canberra Health Services, Canberra, Australian Capital Territory, Australia
Eleni Daskalaki
6 School of Computing, College of Engineering and Computer Science, Australian National University, Canberra, Australian Capital Territory, Australia
Janet Drew
1 National Centre for Epidemiology and Population Health, College of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, Australia
Mark Elisha
1 National Centre for Epidemiology and Population Health, College of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, Australia
Vanessa Fanning
1 National Centre for Epidemiology and Population Health, College of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, Australia
Jessica Herron
4 The Centenary Hospital for Women and Children, Canberra Health Services, Canberra, Australian Capital Territory, Australia
Krishnan Murugappan
8 Nanotechnology Research Lab, Research School of Chemistry, College of Science, Australian National University, Canberra, Australian Capital Territory, Australia
Dragomir Neshev
10 Department of Electronic Materials Engineering, Research School of Physics, College of Science, Australian National University, Canberra, Australian Capital Territory, Australia
Antonio Tricoli
8 Nanotechnology Research Lab, Research School of Chemistry, College of Science, Australian National University, Canberra, Australian Capital Territory, Australia
Introduction The terms ‘precision medicine’ and ‘personalised medicine’ have become key terms in health-related research and in science-related public communication. However, the application of these two concepts and their interpretation in various disciplines are heterogeneous, which also affects research translation and public awareness. This leads to confusion regarding the use and distinction of the two concepts. Our aim is to provide a snapshot of the current understanding of these concepts.Methods and analysis Our study will use Rodgers’ evolutionary concept analysis to systematically examine the current understanding of the concepts ‘precision medicine’ and ‘personalised medicine’ in clinical medicine, biomedicine (incorporating genomics and bioinformatics), health services research, physics, chemistry, engineering, machine learning and artificial intelligence, and to identify their respective attributes (clusters of characteristics) and surrogate and related terms. A systematic search of the literature will be conducted for 2016–2022 using databases relevant to each of these disciplines: ACM Digital Library, CINAHL, Cochrane Library, F1000Research, IEEE Xplore, PubMed/Medline, Science Direct, Scopus and Web of Science. These are among the most representative databases for the included disciplines. We will examine similarities and differences in definitions of ‘precision medicine’ and ‘personalised medicine’ in the respective disciplines and across (sub)disciplines, including attributes of each term. This will enable us to determine how these two concepts are distinguished.Ethics and dissemination Following ethical and research standards, we will comprehensively report the methodology for a systematic analysis following Rodgers’ concept analysis method. Our systematic concept analysis will contribute to the clarification of the two concepts and distinction in their application in given settings and circumstances. Such a broad concept analysis will contribute to non-systematic syntheses of the concepts, or occasional systematic reviews on one of the concepts that have been published in specific disciplines, in order to facilitate interdisciplinary communication, translational medical research and implementation science.
