Nature Communications (Apr 2017)

Chemical labelling for visualizing native AMPA receptors in live neurons

  • Sho Wakayama,
  • Shigeki Kiyonaka,
  • Itaru Arai,
  • Wataru Kakegawa,
  • Shinji Matsuda,
  • Keiji Ibata,
  • Yuri L. Nemoto,
  • Akihiro Kusumi,
  • Michisuke Yuzaki,
  • Itaru Hamachi

DOI
https://doi.org/10.1038/ncomms14850
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

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Visualizing neurotransmitter receptor traffic is fundamental to understanding brain functions, but the current imaging methods can compromise the process. Here, the authors synthesize small fluorescent probes to label endogenous glutamate receptors in cell cultures and brain tissues, without affecting their function.