Nature Communications (Jan 2020)
Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche
- Moritz Middelhoff,
- Henrik Nienhüser,
- Giovanni Valenti,
- H. Carlo Maurer,
- Yoku Hayakawa,
- Ryota Takahashi,
- Woosook Kim,
- Zhengyu Jiang,
- Ermanno Malagola,
- Krystle Cuti,
- Yagnesh Tailor,
- Leah B. Zamechek,
- Bernhard W. Renz,
- Michael Quante,
- Kelley S. Yan,
- Timothy C. Wang
Affiliations
- Moritz Middelhoff
- Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center
- Henrik Nienhüser
- Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center
- Giovanni Valenti
- Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center
- H. Carlo Maurer
- Klinikum rechts der Isar, II. Medizinische Klinik, Technische Universität München
- Yoku Hayakawa
- Graduate School of Medicine, Department of Gastroenterology, The University of Tokyo
- Ryota Takahashi
- Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center
- Woosook Kim
- Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center
- Zhengyu Jiang
- Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center
- Ermanno Malagola
- Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center
- Krystle Cuti
- Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center
- Yagnesh Tailor
- Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center
- Leah B. Zamechek
- Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center
- Bernhard W. Renz
- Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Ludwig-Maximilians-Universität München
- Michael Quante
- Klinikum rechts der Isar, II. Medizinische Klinik, Technische Universität München
- Kelley S. Yan
- Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center
- Timothy C. Wang
- Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center
- DOI
- https://doi.org/10.1038/s41467-019-13850-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Acetylcholine regulates intestinal epithelial secretion via muscarinic Gq-coupled receptors but its role in cell differentiation is unclear. Here, the authors show that Prox1-positive endocrine cells are sensors for the cholinergic intestinal niche and can trigger increased differentiation of enteroendocrine DCLK1-positive tuft cells.
