Hippocampal and prefrontal processing of network topology to simulate the future

Amir-Homayoun Javadi; Beatrix Emo; Lorelei R. Howard; Fiona E. Zisch; Yichao Yu; Rebecca Knight; Joao Pinelo Silva; Hugo J. Spiers

doi:10.1038/ncomms14652

Nature Communications (Mar 2017)

Hippocampal and prefrontal processing of network topology to simulate the future

Amir-Homayoun Javadi,
Beatrix Emo,
Lorelei R. Howard,
Fiona E. Zisch,
Yichao Yu,
Rebecca Knight,
Joao Pinelo Silva,
Hugo J. Spiers

Affiliations

Amir-Homayoun Javadi: School of Psychology, University of Kent
Beatrix Emo: Chair of Cognitive Science
Lorelei R. Howard: Aging and Cognition Research Group, German Center for Neurodegenerative Diseases (DZNE)
Fiona E. Zisch: Division of Psychology and Language Sciences, Department of Experimental Psychology, UCL Institute of Behavioural Neuroscience, University College London
Yichao Yu: UCL Centre for Advanced Biomedical Imaging, University College London
Rebecca Knight: School of Psychology, University of Hertfordshire
Joao Pinelo Silva: Department of Architecture and Interior Design, University of Bahrain 840
Hugo J. Spiers: Division of Psychology and Language Sciences, Department of Experimental Psychology, UCL Institute of Behavioural Neuroscience, University College London

DOI: https://doi.org/10.1038/ncomms14652
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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The hippocampus is known to support navigation, but how it processes possible paths to aid navigation is unknown. Here Javadiet al. show that entering streets drives hippocampal activity corresponding to the number of future paths, and that prefrontal activity corresponds to path-planning demands.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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