Comparison of clinical and angiographic results in COVID-19–positive and –negative patients undergoing primary coronary intervention due to ST-elevation myocardial infarction

Abstract

Introduction: Although coronavirus disease-19 (COVID-19) primarily causes respiratory system infection, it may cause thrombosis in the cardiovascular system. In this regard, we aimed to compare cardiovascular outcomes between COVID-19–positive and –negative patients with ST-segment elevation myocardial infarction (STEMI). Methods: This was a retrospective study that consecutively included 96 COVID − and 36 COVID+ patients with STEMI. Clinical, laboratory, and angiographic characteristics were obtained from hospital records, and these variables were compared between groups. Results: COVID-19 patients with STEMI had higher Killip score (3–4) (78 vs. 30, P < 0.001) and mortality (42% vs. 21%, P = 0.017). Among COVID-19 patients with STEMI, 83% had lung infiltration. According to the angiographic findings, COVID-19 patients had a shorter door to balloon time (35 ± 20 vs. 49 ± 17, P = 0.013), glycoprotein IIb/IIIa antagonist use, and shorter door to balloon time. Conclusion: COVID-19 patients with STEMI had a higher rate of cardiogenic shock and mortality.

Keywords

• acute coronary syndrome
• coagulopathy
• coronavirus disease-19
• severe acute respiratory system syndrome coronavirus-2
• st-segment elevation myocardial infarction