Nature Communications (Nov 2018)

Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels

  • Lina Dobnikar,
  • Annabel L. Taylor,
  • Joel Chappell,
  • Phoebe Oldach,
  • Jennifer L. Harman,
  • Erin Oerton,
  • Elaine Dzierzak,
  • Martin R. Bennett,
  • Mikhail Spivakov,
  • Helle F. Jørgensen

DOI
https://doi.org/10.1038/s41467-018-06891-x
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 17

Abstract

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Vascular smooth muscle cell (VSMC) accumulation is associated with cardiovascular disease. Here, the authors combine single-cell RNA sequencing with lineage labelling to profile VSMC heterogeneity in healthy mice. They show that upregulation of Sca1 in a rare VSMC subpopulation marks a cell phenotype that is prevalent in disease.