Nature Communications (Aug 2018)
Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation
- Fabrizia Bonacina,
- David Coe,
- Guosu Wang,
- Maria P. Longhi,
- Andrea Baragetti,
- Annalisa Moregola,
- Katia Garlaschelli,
- Patrizia Uboldi,
- Fabio Pellegatta,
- Liliana Grigore,
- Lorenzo Da Dalt,
- Andrea Annoni,
- Silvia Gregori,
- Qingzhong Xiao,
- Donatella Caruso,
- Nico Mitro,
- Alberico L. Catapano,
- Federica M. Marelli-Berg,
- Giuseppe D. Norata
Affiliations
- Fabrizia Bonacina
- Department of Pharmacological and Biomolecular Sciences (DisFeB), Università Degli Studi di Milano
- David Coe
- William Harvey Research Institute, Queen Mary University of London
- Guosu Wang
- William Harvey Research Institute, Queen Mary University of London
- Maria P. Longhi
- William Harvey Research Institute, Queen Mary University of London
- Andrea Baragetti
- Department of Pharmacological and Biomolecular Sciences (DisFeB), Università Degli Studi di Milano
- Annalisa Moregola
- Department of Pharmacological and Biomolecular Sciences (DisFeB), Università Degli Studi di Milano
- Katia Garlaschelli
- SISA Centre, Bassini Hospital
- Patrizia Uboldi
- Department of Pharmacological and Biomolecular Sciences (DisFeB), Università Degli Studi di Milano
- Fabio Pellegatta
- SISA Centre, Bassini Hospital
- Liliana Grigore
- SISA Centre, Bassini Hospital
- Lorenzo Da Dalt
- Department of Pharmacological and Biomolecular Sciences (DisFeB), Università Degli Studi di Milano
- Andrea Annoni
- San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute
- Silvia Gregori
- San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), IRCCS San Raffaele Scientific Institute
- Qingzhong Xiao
- William Harvey Research Institute, Queen Mary University of London
- Donatella Caruso
- Department of Pharmacological and Biomolecular Sciences (DisFeB), Università Degli Studi di Milano
- Nico Mitro
- Department of Pharmacological and Biomolecular Sciences (DisFeB), Università Degli Studi di Milano
- Alberico L. Catapano
- Department of Pharmacological and Biomolecular Sciences (DisFeB), Università Degli Studi di Milano
- Federica M. Marelli-Berg
- William Harvey Research Institute, Queen Mary University of London
- Giuseppe D. Norata
- Department of Pharmacological and Biomolecular Sciences (DisFeB), Università Degli Studi di Milano
- DOI
- https://doi.org/10.1038/s41467-018-05322-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
Cholesterol homeostasis can modulate immunity via multiple pathways. Here the authors show that apolipoprotein E, an important regulator of cholesterol, produced by myeloid cells can regulate T cell activation by controlling the antigen presentation activity of dendritic cells in both humans and mice.
