Nature Communications (Oct 2020)
Two distinct immunopathological profiles in autopsy lungs of COVID-19
- Ronny Nienhold,
- Yari Ciani,
- Viktor H. Koelzer,
- Alexandar Tzankov,
- Jasmin D. Haslbauer,
- Thomas Menter,
- Nathalie Schwab,
- Maurice Henkel,
- Angela Frank,
- Veronika Zsikla,
- Niels Willi,
- Werner Kempf,
- Thomas Hoyler,
- Mattia Barbareschi,
- Holger Moch,
- Markus Tolnay,
- Gieri Cathomas,
- Francesca Demichelis,
- Tobias Junt,
- Kirsten D. Mertz
Affiliations
- Ronny Nienhold
- Institute of Pathology, Cantonal Hospital Baselland
- Yari Ciani
- Laboratory of Computational and Functional Oncology, Department for Cellular, Computational and Integrative Biology – CIBIO, University of Trento
- Viktor H. Koelzer
- Department of Pathology and Molecular Pathology, University Hospital Zurich
- Alexandar Tzankov
- Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel
- Jasmin D. Haslbauer
- Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel
- Thomas Menter
- Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel
- Nathalie Schwab
- Institute of Pathology, Cantonal Hospital Baselland
- Maurice Henkel
- Institute of Pathology, Cantonal Hospital Baselland
- Angela Frank
- Institute of Pathology, Cantonal Hospital Baselland
- Veronika Zsikla
- Institute of Pathology, Cantonal Hospital Baselland
- Niels Willi
- Institute of Pathology, Cantonal Hospital Baselland
- Werner Kempf
- Kempf und Pfaltz Histologische Diagnostik
- Thomas Hoyler
- Novartis Institutes for BioMedical Research (NIBR)
- Mattia Barbareschi
- Anatomia ed Istologia Patologica, Ospedale S. Chiara di Trento
- Holger Moch
- Department of Pathology and Molecular Pathology, University Hospital Zurich
- Markus Tolnay
- Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel
- Gieri Cathomas
- Institute of Pathology, Cantonal Hospital Baselland
- Francesca Demichelis
- Laboratory of Computational and Functional Oncology, Department for Cellular, Computational and Integrative Biology – CIBIO, University of Trento
- Tobias Junt
- Novartis Institutes for BioMedical Research (NIBR)
- Kirsten D. Mertz
- Institute of Pathology, Cantonal Hospital Baselland
- DOI
- https://doi.org/10.1038/s41467-020-18854-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
The immunopathological features of SARS-CoV-2 infection in the lungs remain unclear. Here, the authors provide a comprehensive characterization of post mortem lung tissues of COVID-19 patients and find two distinct patterns characterized by differential expression of interferon stimulated genes (ISGs), which correlate to viral loads, cytokines, lung damage and time of hospitalization, suggesting ISG profiles to mark disease progression
