Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics

Abstract

While translational regulation of p53 by the internal ribosome entry site (IRES) at its 5′-untranslated region following DNA damage has been widely accepted, the detailed mechanism underlying the translational control of p53 by its IRES sequence is still poorly understood. In this review, we will focus on the latest progress in identifying novel regulatory proteins of the p53 IRES and in uncovering the functional connection between defective IRES-mediated p53 translation and tumorigenesis. We will also discuss how these findings may lead to a better understanding of the process of oncogenesis and open up new avenues for cancer diagnosis and therapeutics.

Keywords

• p53
• internal ribosome entry site (IRES)
• DNA damage
• IRES-trans acting factors (ITAFs)