The Relationship Between Prediabetes With Peripheral Pulse Wave Values and Carotid Intima-Media Thickness

Abstract

INTRODUCTION: This study was conducted to reveal whether there is a relationship between prediabetes and arterial stiffness. METHODS: Patients diagnosed with prediabetes in the endocrine outpatient clinic and healthy volunteers without any previous disease history were included in this study. Those with diabetes, hypertension, previous myocardial infarction, and those using antihypertensive drugs were excluded from the study. First, the mean carotid intima-media thickness (CIMT) values in the right and left internal carotid arteries were calculated with an ultrasonography device. The mean CIMT value was obtained by taking the average of these two values. Then, pulse wave values were recorded using ECG and photoplethysmography electrodes with the help of the EMG device. Mann-Whitney U, Chi-Square and Spearman's rho tests were used for statistical analysis. RESULTS: A total of 46 individuals, 27 of whom were prediabetes and 19 of whom were control group, participated in the study. While there was no significant difference between the control and the prediabetes group in terms of age, low and high-density lipoprotein, cholesterol, triglyceride, and insulin, there was a significant difference in terms of fasting blood glucose, body mass index, mean CIMT and pulse wave transition time (p<0.05). In the correlation analysis, no significant relationship was found between CIMT (right, left, and mean) and pulse wave velocity or transition time. DISCUSSION AND CONCLUSION: In this study, it was determined that the pulse wave transition time was significantly shorter and the carotid intima-media thickness was higher in prediabetes patients than in the control group.

Keywords

• arterial stiffness
• electromyography
• photoplethysmography
• internal carotid artery