A new strategy for the determination of the antidiabetics alogliptin, saxagliptin and vildagliptin using all-solid state potentiometric sensors

Abstract

Abstract Herein, we report on the development of disposable screen printed carbon, nanostructure thin film Au/Pt and Pt/Pt all-solid state potentiometric sensors for some antidiabetic compounds called glibtins. The electrodes showed excellent calibration curves (1 × 10–5–1 × 10–2 M) for alogliptin, saxagliptin and vildagliptin. The electrodes were fully characterized with respect to potential stability, dynamic response time, detection limit, effect of pH and interference according to the IUPAC recommendation. The proposed method is rapid and can be applied for the determination of gliptins at low cost with satisfactory precision (RSD ≤ 1%) and accuracy.

Keywords

• Screen printed ion selective electrode
• Au and Pt nanoparticles
• All-solid-state electrode
• Coated wire
• Dipeptidyl peptidase-4 inhibitors