Dietary fat modulation of apoA-II metabolism and prevention of senile amyloidosis in the senescence- accelerated mouse

Makiko Umezawa; Kenjiro Tatematsu; Tatsumi Korenaga; Xiaoying Fu; Takatoshi Matushita; Harumi Okuyama; Masanori Hosokawa; Toshio Takeda; Keiichi Higuchi

Journal of Lipid Research (Apr 2003)

Dietary fat modulation of apoA-II metabolism and prevention of senile amyloidosis in the senescence- accelerated mouse

Makiko Umezawa,
Kenjiro Tatematsu,
Tatsumi Korenaga,
Xiaoying Fu,
Takatoshi Matushita,
Harumi Okuyama,
Masanori Hosokawa,
Toshio Takeda,
Keiichi Higuchi

Affiliations

Makiko Umezawa: Department of Nutrition, Koshien University, 10-1 Momijigaoka, Takarazuka, Hyogo 665-0006, Japan; Department of Preventive Nutraceutical Sciences, Graduate School of Pharmaceutical Biological Chemistry, Nagoya City University, Nagoya 467-8603, Japan; Field of Regeneration Control, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8397, Japan; Department of Aging Angiology, Research Center on Aging and Adaptation, Shinshu University School of Medicine, Matsumoto 390-8621, Japan
Kenjiro Tatematsu: Department of Nutrition, Koshien University, 10-1 Momijigaoka, Takarazuka, Hyogo 665-0006, Japan; Department of Preventive Nutraceutical Sciences, Graduate School of Pharmaceutical Biological Chemistry, Nagoya City University, Nagoya 467-8603, Japan; Field of Regeneration Control, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8397, Japan; Department of Aging Angiology, Research Center on Aging and Adaptation, Shinshu University School of Medicine, Matsumoto 390-8621, Japan
Tatsumi Korenaga: Department of Nutrition, Koshien University, 10-1 Momijigaoka, Takarazuka, Hyogo 665-0006, Japan; Department of Preventive Nutraceutical Sciences, Graduate School of Pharmaceutical Biological Chemistry, Nagoya City University, Nagoya 467-8603, Japan; Field of Regeneration Control, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8397, Japan; Department of Aging Angiology, Research Center on Aging and Adaptation, Shinshu University School of Medicine, Matsumoto 390-8621, Japan
Xiaoying Fu: Department of Nutrition, Koshien University, 10-1 Momijigaoka, Takarazuka, Hyogo 665-0006, Japan; Department of Preventive Nutraceutical Sciences, Graduate School of Pharmaceutical Biological Chemistry, Nagoya City University, Nagoya 467-8603, Japan; Field of Regeneration Control, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8397, Japan; Department of Aging Angiology, Research Center on Aging and Adaptation, Shinshu University School of Medicine, Matsumoto 390-8621, Japan
Takatoshi Matushita: Department of Nutrition, Koshien University, 10-1 Momijigaoka, Takarazuka, Hyogo 665-0006, Japan; Department of Preventive Nutraceutical Sciences, Graduate School of Pharmaceutical Biological Chemistry, Nagoya City University, Nagoya 467-8603, Japan; Field of Regeneration Control, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8397, Japan; Department of Aging Angiology, Research Center on Aging and Adaptation, Shinshu University School of Medicine, Matsumoto 390-8621, Japan
Harumi Okuyama: Department of Nutrition, Koshien University, 10-1 Momijigaoka, Takarazuka, Hyogo 665-0006, Japan; Department of Preventive Nutraceutical Sciences, Graduate School of Pharmaceutical Biological Chemistry, Nagoya City University, Nagoya 467-8603, Japan; Field of Regeneration Control, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8397, Japan; Department of Aging Angiology, Research Center on Aging and Adaptation, Shinshu University School of Medicine, Matsumoto 390-8621, Japan
Masanori Hosokawa: Department of Nutrition, Koshien University, 10-1 Momijigaoka, Takarazuka, Hyogo 665-0006, Japan; Department of Preventive Nutraceutical Sciences, Graduate School of Pharmaceutical Biological Chemistry, Nagoya City University, Nagoya 467-8603, Japan; Field of Regeneration Control, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8397, Japan; Department of Aging Angiology, Research Center on Aging and Adaptation, Shinshu University School of Medicine, Matsumoto 390-8621, Japan
Toshio Takeda: Department of Nutrition, Koshien University, 10-1 Momijigaoka, Takarazuka, Hyogo 665-0006, Japan; Department of Preventive Nutraceutical Sciences, Graduate School of Pharmaceutical Biological Chemistry, Nagoya City University, Nagoya 467-8603, Japan; Field of Regeneration Control, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8397, Japan; Department of Aging Angiology, Research Center on Aging and Adaptation, Shinshu University School of Medicine, Matsumoto 390-8621, Japan
Keiichi Higuchi: Department of Nutrition, Koshien University, 10-1 Momijigaoka, Takarazuka, Hyogo 665-0006, Japan; Department of Preventive Nutraceutical Sciences, Graduate School of Pharmaceutical Biological Chemistry, Nagoya City University, Nagoya 467-8603, Japan; Field of Regeneration Control, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8397, Japan; Department of Aging Angiology, Research Center on Aging and Adaptation, Shinshu University School of Medicine, Matsumoto 390-8621, Japan

Journal volume & issue: Vol. 44, no. 4
pp. 762 – 769

Abstract

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Senescence-accelerated mouse-prone (SAMP1; SAMP1@Umz) is an animal model of senile amyloidosis with apolipoprotein A-II (apoA-II) amyloid fibril (AApoAII) deposits. This study was undertaken to investigate the effects of dietary fats on AApoAII deposits in SAMP1 mice when purified diets containing 4% fat as butter, safflower oil, or fish oil were fed to male mice for 26 weeks. The serum HDL cholesterol was significantly lower (P butter > safflower oil group, P < 0.05).These findings suggest that dietary fats differ in their effects on serum lipoprotein metabolism, and that dietary lipids may modulate amyloid deposition in SAMP1 mice.

Published in Journal of Lipid Research

ISSN: 0022-2275 (Print); 1539-7262 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science: Chemistry: Organic chemistry: Biochemistry
Website: https://www.journals.elsevier.com/journal-of-lipid-research

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