Nature Communications (Jan 2021)
CREPT is required for murine stem cell maintenance during intestinal regeneration
- Liu Yang,
- Haiyan Yang,
- Yunxiang Chu,
- Yunhao Song,
- Lidan Ding,
- Bingtao Zhu,
- Wanli Zhai,
- Xuning Wang,
- Yanshen Kuang,
- Fangli Ren,
- Baoqing Jia,
- Wei Wu,
- Xiongjun Ye,
- Yinyin Wang,
- Zhijie Chang
Affiliations
- Liu Yang
- State Key Laboratory of Membrane Biology, School of Medicine, Center for Synthetic and Systems Biology, Tsinghua University
- Haiyan Yang
- MOE Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University
- Yunxiang Chu
- Department of Gastroenterology, Emergency General Hospital
- Yunhao Song
- State Key Laboratory of Membrane Biology, School of Medicine, Center for Synthetic and Systems Biology, Tsinghua University
- Lidan Ding
- State Key Laboratory of Membrane Biology, School of Medicine, Center for Synthetic and Systems Biology, Tsinghua University
- Bingtao Zhu
- State Key Laboratory of Membrane Biology, School of Medicine, Center for Synthetic and Systems Biology, Tsinghua University
- Wanli Zhai
- State Key Laboratory of Membrane Biology, School of Medicine, Center for Synthetic and Systems Biology, Tsinghua University
- Xuning Wang
- Department of Gastroenterology, Chinese PLA General Hospital
- Yanshen Kuang
- Department of Gastroenterology, Chinese PLA General Hospital
- Fangli Ren
- State Key Laboratory of Membrane Biology, School of Medicine, Center for Synthetic and Systems Biology, Tsinghua University
- Baoqing Jia
- Department of Gastroenterology, Chinese PLA General Hospital
- Wei Wu
- MOE Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University
- Xiongjun Ye
- Urology and Lithotripsy Center, Peking University People’s Hospital
- Yinyin Wang
- State Key Laboratory of Membrane Biology, School of Medicine, Center for Synthetic and Systems Biology, Tsinghua University
- Zhijie Chang
- State Key Laboratory of Membrane Biology, School of Medicine, Center for Synthetic and Systems Biology, Tsinghua University
- DOI
- https://doi.org/10.1038/s41467-020-20636-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
The role of CREPT, a recently identified tumor-promoting gene, outside of tumors is unclear. Here, the authors identify CREPT as maintaining murine intestinal stem cells, with embryonic deletion causing impaired cell proliferation and regeneration.
