Four new lanostane triterpenoids featuring extended π-conjugated systems from the stems of Kadsura coccinea

Abstract

Abstract Four new 14(13 → 12)-abeolanostane triterpenoids featuring extended π-conjugated systems, kadcoccitanes E–H (1–4), were obtained from the stems of Kadsura coccinea through using a HPLC − UV-guided approach. Their structural and configurational determination was accomplished through extensive spectroscopic analysis coupled with quantum chemical calculations. Kadcoccitanes E–H were tested for their cytotoxic activities against five human tumor cell lines (HL-60, A-549, SMMC-7721, MDA-MB-231, SW-480) but none of them exhibited activities at the concentration 40 μM. Graphical Abstract

Keywords

• Kadsura coccinea
• Lanostane triterpenoids
• Extended π-conjugated systems
• Quantum chemical calculation