Nature Communications (Feb 2019)

A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP

  • Mark A. Lobas,
  • Rongkun Tao,
  • Jun Nagai,
  • Mira T. Kronschläger,
  • Philip M. Borden,
  • Jonathan S. Marvin,
  • Loren L. Looger,
  • Baljit S. Khakh

DOI
https://doi.org/10.1038/s41467-019-08441-5
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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ATP has essential roles in cell signalling and energy homeostasis and biosensors to detect it have many potential applications. Here, the authors develop a new ATP sensor that can be targeted to the membrane or cytosol.