Hepatoprotective effect of water bamboo shoot (Zizania latifolia) extracts against acute alcoholic liver injury in a mice model and screening of bioactive phytochemicals

Yuan Gao; Zihao Zong; Wei Xia; Xiangjun Fang; Ruiling Liu; Weijie Wu; Honglei Mu; Yanchao Han; Shangyue Xiao; Haiyan Gao; Hangjun Chen

doi:10.1002/fft2.217

Food Frontiers (Sep 2023)

Hepatoprotective effect of water bamboo shoot (Zizania latifolia) extracts against acute alcoholic liver injury in a mice model and screening of bioactive phytochemicals

Yuan Gao,
Zihao Zong,
Wei Xia,
Xiangjun Fang,
Ruiling Liu,
Weijie Wu,
Honglei Mu,
Yanchao Han,
Shangyue Xiao,
Haiyan Gao,
Hangjun Chen

Affiliations

Yuan Gao: Key Laboratory of Post‐Harvest Handling of Fruits, Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang Province, Key Laboratory of Postharvest Preservation and Processing of Fruits and Vegetables, China National Light Industry, Key Laboratory of Postharvest Preservation and Processing of Vegetables (Co‐construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Institute of Food Science Zhejiang Academy of Agricultural Sciences Hangzhou China
Zihao Zong: Key Laboratory of Post‐Harvest Handling of Fruits, Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang Province, Key Laboratory of Postharvest Preservation and Processing of Fruits and Vegetables, China National Light Industry, Key Laboratory of Postharvest Preservation and Processing of Vegetables (Co‐construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Institute of Food Science Zhejiang Academy of Agricultural Sciences Hangzhou China
Wei Xia: Key Laboratory of Post‐Harvest Handling of Fruits, Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang Province, Key Laboratory of Postharvest Preservation and Processing of Fruits and Vegetables, China National Light Industry, Key Laboratory of Postharvest Preservation and Processing of Vegetables (Co‐construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Institute of Food Science Zhejiang Academy of Agricultural Sciences Hangzhou China
Xiangjun Fang: Key Laboratory of Post‐Harvest Handling of Fruits, Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang Province, Key Laboratory of Postharvest Preservation and Processing of Fruits and Vegetables, China National Light Industry, Key Laboratory of Postharvest Preservation and Processing of Vegetables (Co‐construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Institute of Food Science Zhejiang Academy of Agricultural Sciences Hangzhou China
Ruiling Liu: Key Laboratory of Post‐Harvest Handling of Fruits, Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang Province, Key Laboratory of Postharvest Preservation and Processing of Fruits and Vegetables, China National Light Industry, Key Laboratory of Postharvest Preservation and Processing of Vegetables (Co‐construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Institute of Food Science Zhejiang Academy of Agricultural Sciences Hangzhou China
Weijie Wu: Key Laboratory of Post‐Harvest Handling of Fruits, Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang Province, Key Laboratory of Postharvest Preservation and Processing of Fruits and Vegetables, China National Light Industry, Key Laboratory of Postharvest Preservation and Processing of Vegetables (Co‐construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Institute of Food Science Zhejiang Academy of Agricultural Sciences Hangzhou China
Honglei Mu: Key Laboratory of Post‐Harvest Handling of Fruits, Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang Province, Key Laboratory of Postharvest Preservation and Processing of Fruits and Vegetables, China National Light Industry, Key Laboratory of Postharvest Preservation and Processing of Vegetables (Co‐construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Institute of Food Science Zhejiang Academy of Agricultural Sciences Hangzhou China
Yanchao Han: Key Laboratory of Post‐Harvest Handling of Fruits, Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang Province, Key Laboratory of Postharvest Preservation and Processing of Fruits and Vegetables, China National Light Industry, Key Laboratory of Postharvest Preservation and Processing of Vegetables (Co‐construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Institute of Food Science Zhejiang Academy of Agricultural Sciences Hangzhou China
Shangyue Xiao: Key Laboratory of Post‐Harvest Handling of Fruits, Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang Province, Key Laboratory of Postharvest Preservation and Processing of Fruits and Vegetables, China National Light Industry, Key Laboratory of Postharvest Preservation and Processing of Vegetables (Co‐construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Institute of Food Science Zhejiang Academy of Agricultural Sciences Hangzhou China
Haiyan Gao: Key Laboratory of Post‐Harvest Handling of Fruits, Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang Province, Key Laboratory of Postharvest Preservation and Processing of Fruits and Vegetables, China National Light Industry, Key Laboratory of Postharvest Preservation and Processing of Vegetables (Co‐construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Institute of Food Science Zhejiang Academy of Agricultural Sciences Hangzhou China
Hangjun Chen: Key Laboratory of Post‐Harvest Handling of Fruits, Key Laboratory of Fruits and Vegetables Postharvest and Processing Technology Research of Zhejiang Province, Key Laboratory of Postharvest Preservation and Processing of Fruits and Vegetables, China National Light Industry, Key Laboratory of Postharvest Preservation and Processing of Vegetables (Co‐construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Institute of Food Science Zhejiang Academy of Agricultural Sciences Hangzhou China

DOI: https://doi.org/10.1002/fft2.217
Journal volume & issue: Vol. 4, no. 3
pp. 1362 – 1371

Abstract

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Abstract In this study, the hepatoprotective effect of alkali extract (NE) of water bamboo shoot (WBS) against acute alcoholic liver injury (ALI) in mice was evaluated, and its underlying mechanisms were explored. Animal experiment demonstrated that NE exhibited hepatoprotective effect on alcoholic intake‐induced ALI via significantly enhancing the hepatic activities of alcohol dehydrogenase (ADH), acetaldehyde dehydrogenase (ALDH), superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px), and catalase (CAT), whereas significantly attenuated hepatic levels of malondialdehyde (MDA), interleukin‐1β (IL‐1β), interleukin‐6 (IL‐6), and tumor necrosis factor‐α (TNF‐α). The potential molecular mechanism and bioactive compounds of NE against ALI were explored by bioinformatics analysis and isosinensetin was found to be the major bioactive compounds in NE against ALI. The western blot analysis showed that NE inhibited phosphorylation of p65 and IκBα to suppress the NF‐κB pathway. Overall our result indicated that WBS possesses potential hepatoprotective effects against ALI.

Published in Food Frontiers

ISSN: 2643-8429 (Online)
Publisher: Wiley
Country of publisher: Australia
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply; Technology: Chemical technology: Food processing and manufacture
Website: https://onlinelibrary.wiley.com/journal/26438429

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