MHC class II deficiency. Description of a clinical case

Abstract

Currently, primary immunodeficiencies (PID) are becoming an increasingly relevant issue: it is now evident that this is not such a rare pathology as previously thought. According to the Immune Deficiency Foundation (USA), the total number of PID patients exceeds that of cystic fibrosis four-fold. Despite this, physician awareness of the disease is extremely low. The modern methods of diagnosis and treatment help the patients survive into adulthood. Patients with PID may get an appointment with any doctor: therapist, pulmonologist, hematologist, gastroenterologist, etc. since clinical manifestations of this disease are very diverse. Due to the fact that the prognosis for PID patients is determined by timeliness and adequacy of prescribed therapy, it is essential to study the various forms of PID to obtain new insights into the structure and principles of the human immune system.

Keywords

• первичные иммунодефициты
• дефицит молекул главного комплекса гистосовместимости (mhc) ii типа
• аутосомно-рецессивный тип наследования
• иммуноглобулины для внутривенного введения
• primary immunodeficiencies
• major histocompatibility complex class ii defici