Clinical Ophthalmology (Oct 2021)

Vessel Evaluation in Patients with Primary Open-Angle Glaucoma, Normal Tension Glaucoma and Healthy Controls

  • Kortuem C,
  • Dietter J,
  • Bozkurt Y,
  • Kortuem FC,
  • Abaza A,
  • Wahl S,
  • Ivanov IV,
  • Ueffing M,
  • Voykov B

Journal volume & issue
Vol. Volume 15
pp. 4269 – 4280

Abstract

Read online

Constanze Kortuem,1,* Johannes Dietter,2,* Yagmur Bozkurt,2 Friederike Charlotte Kortuem,1 Annegret Abaza,1 Siegfried Wahl,2,3 Iliya V Ivanov,2,3 Marius Ueffing,2 Bogomil Voykov1 1Department of Ophthalmology, University Eye Hospital, Eberhard Karls University Tuebingen, Tuebingen, Germany; 2Department of Ophthalmology, Institute for Ophthalmic Research University of Tuebingen, Tuebingen, Germany; 3Carl Zeiss Vision International GmbH, Aalen, Germany*These authors contributed equally to this workCorrespondence: Constanze KortuemDepartment of Ophthalmology, Eberhard Karls University Tuebingen, Elfriede-Aulhorn-Str. 7, Tuebingen, 72076, GermanyTel +49 7071 29-88687Fax +49 7071 293749Email [email protected]: To compare changes in central retinal arterial equivalent (CRAE), central retinal vein equivalent (CRVE), arteriovenous ratio (AVR), tortuosity and fractal dimension in primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG) and in a control group (CG) on fundus photographs. Further, to provide further evidence of vascular change in glaucoma patients using a novel method of tortuosity.Patients and Methods: The primary endpoint was the change in CRAE, CRVE, AVR, fractal dimension and tortuosity of the retinal vasculature from baseline, retrospectively analyzed from 2011 to 2017 at the University Eye Hospital Tuebingen. Fundus photos of POAG (N = 49), NTG (N = 38) and CG (N = 18) were computer evaluated and analyzed in the quantities mentioned above.Results: CRAE in NTG and POAG and CRVE in NTG significantly decreased (P = 0.02, P = 0.01; P = 0.03) whereas CRVE in POAG increased insignificantly (P = 0.72). In NTG, AVR decreased significantly (P = 0.05), but to a lesser extent than in POAG (P < 0.001). In CG, CRAE decreased insignificantly (P = 0.10), CRVE decreased significantly (P = 0.03) and AVR increased insignificantly (P = 0.77). In POAG tortuosity calculated using standard methods as well as our novel method, increased significantly (P = 0.015– 0.04), whereas it did not occur in NTG (P = 0.18– 0.57) and CG (P = 0.11– 0.21). Fractal dimensions in POAG decreased significantly (P = 0.001– 0.002), whereas in NTG and CG changes were insignificant (P = 0.33– 0.92).Conclusion: Based on a retrospective analysis of fundus photographs, specific retinal vasculature features of the retinal vasculature display significant alterations associated with NTG and POAG. The assessment of tortuosity using our novel method was consistent with previously established methods for analyzing tortuosity.Keywords: AVR, CRAE, CRVE, tortuosity of vessels, fractal dimensions

Keywords