Nature Communications (Aug 2017)
Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance
- Baptiste Rode,
- Jian Shi,
- Naima Endesh,
- Mark J. Drinkhill,
- Peter J. Webster,
- Sabine J. Lotteau,
- Marc A. Bailey,
- Nadira Y. Yuldasheva,
- Melanie J. Ludlow,
- Richard M. Cubbon,
- Jing Li,
- T. Simon Futers,
- Lara Morley,
- Hannah J. Gaunt,
- Katarzyna Marszalek,
- Hema Viswambharan,
- Kevin Cuthbertson,
- Paul D. Baxter,
- Richard Foster,
- Piruthivi Sukumar,
- Andrew Weightman,
- Sarah C. Calaghan,
- Stephen B. Wheatcroft,
- Mark T. Kearney,
- David J. Beech
Affiliations
- Baptiste Rode
- Schools of Medicine, University of Leeds
- Jian Shi
- Schools of Medicine, University of Leeds
- Naima Endesh
- Schools of Medicine, University of Leeds
- Mark J. Drinkhill
- Schools of Medicine, University of Leeds
- Peter J. Webster
- Schools of Medicine, University of Leeds
- Sabine J. Lotteau
- School of Biomedical Sciences, University of Leeds
- Marc A. Bailey
- Schools of Medicine, University of Leeds
- Nadira Y. Yuldasheva
- Schools of Medicine, University of Leeds
- Melanie J. Ludlow
- Schools of Medicine, University of Leeds
- Richard M. Cubbon
- Schools of Medicine, University of Leeds
- Jing Li
- Schools of Medicine, University of Leeds
- T. Simon Futers
- Schools of Medicine, University of Leeds
- Lara Morley
- Schools of Medicine, University of Leeds
- Hannah J. Gaunt
- Schools of Medicine, University of Leeds
- Katarzyna Marszalek
- Schools of Medicine, University of Leeds
- Hema Viswambharan
- Schools of Medicine, University of Leeds
- Kevin Cuthbertson
- School of Chemistry, University of Leeds
- Paul D. Baxter
- Schools of Medicine, University of Leeds
- Richard Foster
- School of Chemistry, University of Leeds
- Piruthivi Sukumar
- Schools of Medicine, University of Leeds
- Andrew Weightman
- School of Mechanical, Aerospace and Civil Engineering, University of Manchester
- Sarah C. Calaghan
- School of Biomedical Sciences, University of Leeds
- Stephen B. Wheatcroft
- Schools of Medicine, University of Leeds
- Mark T. Kearney
- Schools of Medicine, University of Leeds
- David J. Beech
- Schools of Medicine, University of Leeds
- DOI
- https://doi.org/10.1038/s41467-017-00429-3
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
The mechanisms that regulate the body’s response to exercise are poorly understood. Here, Rode et al. show that the mechanically activated cation channel Piezo1 is a molecular sensor of physical exercise in the endothelium that triggers endothelial communication to mesenteric vessel muscle cells, leading to vasoconstriction.
