Nature Communications (Nov 2017)

Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells

  • Ana Filipa Gonçalves,
  • Mojca Adlesic,
  • Simone Brandt,
  • Tomas Hejhal,
  • Sabine Harlander,
  • Lukas Sommer,
  • Olga Shakhova,
  • Peter J. Wild,
  • Ian J. Frew

DOI
https://doi.org/10.1038/s41467-017-01514-3
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 16

Abstract

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Renal angiomyolipomas (AML) contain a mix of clonal tumour cells. Here, through reverse tumour engineering experiments, mouse genetics and analyses of human AML tumours, the authors provide evidence that these mesenchymal tumours originate from renal proximal tubule epithelial cells.