Synthesis of (macro)heterocycles by consecutive/repetitive isocyanide-based multicomponent reactions

Abstract

Isocyanide-based multicomponent reactions are a versatile tool in the synthesis of heterocycles. This review describes recently developed approaches based on the combination of consecutive or repetitive isocyanide-based multicomponent reactions for the synthesis of structurally diverse heterocycles. These strategies have also allowed the synthesis of a plethora of macroheterocycles in a reduced number of steps.

Keywords

• consecutive/repetitive multicomponent reactions
• isocyanide
• isocyanide-based multicomponent reactions
• (macro)heterocycles
• Passerini reaction
• Ugi reaction