Бюллетень сибирской медицины (Dec 2018)

Hypotensive effect of bi-potassium salt of 1-hexadecyl-2-methylcarbamoylphosphatidic acid in rats with renovascular hypertension

  • N. Y. Khromova,
  • S. I. Malekin,
  • S. A. Gavrilova,
  • S. V. Kotelevtsev,
  • Yu. V. Kotelevtsev

DOI
https://doi.org/10.20538/1682-0363-2018-4-163-170
Journal volume & issue
Vol. 17, no. 4
pp. 163 – 170

Abstract

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The study describes the synthesis and hypotensive effects of stable platelet activation factor (PAF) precursor 1-hexadecyl-2-m ethylcarbamoyl-phosphatidic acid (HMCP) оn outbred Wistar rats with 1-kidney 1-clip (1K1C) renovascular hypertension. Intravenous injection of 0.1, 0.5, 1 and 5 mg/kg HMCP resulted in a sharp decline of up to 50% of MAP with subsequent restoration to initial level. In some hypertensive 1K1C rats HMCP has a prolonged effect with blood pressure stabilized at 75% of initial level after 30 min post injection. HMCP was toxic at higher doses with a LD50 around 3 mg/kg.

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