Nature Communications (Jan 2018)

Network connectivity determines cortical thinning in early Parkinson’s disease progression

  • Y. Yau,
  • Y. Zeighami,
  • T. E. Baker,
  • K. Larcher,
  • U. Vainik,
  • M. Dadar,
  • V. S. Fonov,
  • P. Hagmann,
  • A. Griffa,
  • B. Mišić,
  • D. L. Collins,
  • A. Dagher

DOI
https://doi.org/10.1038/s41467-017-02416-0
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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In Parkinson’s disease (PD), neurodegeneration spreads from the brainstem to the cerebral cortex. Here, in a longitudinal study of PD patients, the authors found that cortical thinning followed neural connectivity from a “disease reservoir”.