Department of Cardiology, 44 Kindi Street, Istishari Hospital, Amman 11184
Majeda Jallad
Department of Obstetrics and Gynecology, 44 Kindi Street, Istishari Hospital, Amman 11184
Yousef Khader
Department of Public Health, Jordan University of Science and Technology School of Medicine, 3300 Ramtha Road, Irbid 22110
Yahya Badaineh
Department of Cardiology, 44 Kindi Street, Istishari Hospital, Amman 11184
Ramzi A. Tabbalat
Department of Cardiology, Abdali Hospital, 1 Al-Istethmar Street, Abdali Boulevard, Amman 11191
Hasan Zammar
Department of Cardiology, European Gaza Hospital, 12 Khan Yunis Street, Gaza P950, Gaza Strip
Hanna Al-Makhamreh
Department of Internal Medicine, Section of Cardiology, Jordan University Hospital, 100 Queen Rania Street, Amman 11910
Asma Basha
Department of Obstetrics and Gynecology, Jordan University Hospital, 100 Queen Rania Street, Amman 11910
Liyan AlAtteili
Department of Medical Education, University of Jordan School of Medicine, 100 Queen Rania Street, Amman 11910
Raghad Abuhalimeh
Department of Medical Education, University of Jordan School of Medicine, 100 Queen Rania Street, Amman 11910
Taima Fkheideh
Department of Medical Education, University of Jordan School of Medicine, 100 Queen Rania Street, Amman 11910
Amr Ababneh
Department of Medical Education, Jordan University of Science and Technology School of Medicine, Department of Medical Education, 3300 Ramtha Road, Irbid 22110
Layan Ababneh
Department of Medical Education, Jordan University of Science and Technology School of Medicine, Department of Medical Education, 3300 Ramtha Road, Irbid 22110
Saad A. Mahmoud
Department of Internal Medicine, King Abdullah University Hospital, 3300 Ramtha Road, Irbid 22110
Background: There is paucity of data on the prevalence of novel and traditional cardiovascular risk factors in young women with atherosclerotic cardiovascular disease (ASCVD) in the Middle East. We sought to evaluate clinical profiles and prevalence of novel and traditional risk factors in Middle Eastern young women with ASCVD compared with age-matched controls. Methods: Women 18–50 years of age who have ASCVD were enrolled and each was aged-matched with two women with no ASCVD. Prevalence of novel and traditional risk factors was compared in the two groups. Multivariable analyzes examined the independent association of 16 factors with ASCVD. Results: Of 627 young women enrolled mean age 44.1 ± 5.2 years; 209 had ASCVD and 418 served as controls. Women with ASCVD had significantly higher prevalence of five of the studied traditional risk factors (hypertension, type 2 diabetes [T2D], smoking, low-density lipoprotein cholesterol serum levels, and family history of premature ASCVD [FHx]) than women with no ASCVD. Additionally, of the 11 novel and psychosocial risk factors studied, four showed significantly higher prevalence in young women with ASCVD (preterm delivery, hypertensive disease of pregnancy gestational diabetes, and low level of education). Multivariable analyzes showed hypertension, T2D, smoking, FHx, persistent weight gain after pregnancy and low level of education were independently associated with ASCVD. Conclusions: In this study of young Middle Eastern women; traditional risk factors as well as persistent weight gain after pregnancy were more prevalent in women with ASCVD compared with controls. The study is registered with ClinicalTrials.gov, unique identifier number NCT04975503.
