Molecules (Feb 2022)

Hf(OTf)<sub>4</sub>-Catalyzed Three-Component Synthesis of <i>N</i>-Carbamate-Protected β-Amino Ketones

  • Zhen-Zhen Chen,
  • Dong-Zhao Yang,
  • Ying-Ying Dong,
  • Mei Chi,
  • Shou-Zhi Pu,
  • Qi Sun

DOI
https://doi.org/10.3390/molecules27031122
Journal volume & issue
Vol. 27, no. 3
p. 1122

Abstract

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Hafnium(IV) triflate (Hf(OTf)4) has been identified as a potent catalyst for the direct three-component synthesis of β-carbamate ketones. This new method, featuring a low catalyst loading, fast reaction rate, and solvent-free conditions, provided facile access to a diversity of carbamate-protected Mannich bases. A mechanistic investigation indicated that the three-component reaction proceeds via sequential aldol condensation and aza-Michael addition, but not the Mannich-type pathway.

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