Nature Communications (Sep 2016)
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus
- Kate Lawrenson,
- Siddhartha Kar,
- Karen McCue,
- Karoline Kuchenbaeker,
- Kyriaki Michailidou,
- Jonathan Tyrer,
- Jonathan Beesley,
- Susan J. Ramus,
- Qiyuan Li,
- Melissa K. Delgado,
- Janet M. Lee,
- Kristiina Aittomäki,
- Irene L. Andrulis,
- Hoda Anton-Culver,
- Volker Arndt,
- Banu K. Arun,
- Brita Arver,
- Elisa V. Bandera,
- Monica Barile,
- Rosa B. Barkardottir,
- Daniel Barrowdale,
- Matthias W. Beckmann,
- Javier Benitez,
- Andrew Berchuck,
- Maria Bisogna,
- Line Bjorge,
- Carl Blomqvist,
- William Blot,
- Natalia Bogdanova,
- Anders Bojesen,
- Stig E. Bojesen,
- Manjeet K. Bolla,
- Bernardo Bonanni,
- Anne-Lise Børresen-Dale,
- Hiltrud Brauch,
- Paul Brennan,
- Hermann Brenner,
- Fiona Bruinsma,
- Joan Brunet,
- Shaik Ahmad Buhari,
- Barbara Burwinkel,
- Ralf Butzow,
- Saundra S. Buys,
- Qiuyin Cai,
- Trinidad Caldes,
- Ian Campbell,
- Rikki Canniotto,
- Jenny Chang-Claude,
- Jocelyne Chiquette,
- Ji-Yeob Choi,
- Kathleen B. M. Claes,
- GEMO Study Collaborators,
- Linda S. Cook,
- Angela Cox,
- Daniel W. Cramer,
- Simon S. Cross,
- Cezary Cybulski,
- Kamila Czene,
- Mary B. Daly,
- Francesca Damiola,
- Agnieszka Dansonka-Mieszkowska,
- Hatef Darabi,
- Joe Dennis,
- Peter Devilee,
- Orland Diez,
- Jennifer A. Doherty,
- Susan M. Domchek,
- Cecilia M. Dorfling,
- Thilo Dörk,
- Martine Dumont,
- Hans Ehrencrona,
- Bent Ejlertsen,
- Steve Ellis,
- EMBRACE,
- Christoph Engel,
- Eunjung Lee,
- D. Gareth Evans,
- Peter A. Fasching,
- Lidia Feliubadalo,
- Jonine Figueroa,
- Dieter Flesch-Janys,
- Olivia Fletcher,
- Henrik Flyger,
- Lenka Foretova,
- Florentia Fostira,
- William D. Foulkes,
- Brooke L. Fridley,
- Eitan Friedman,
- Debra Frost,
- Gaetana Gambino,
- Patricia A. Ganz,
- Judy Garber,
- Montserrat García-Closas,
- Aleksandra Gentry-Maharaj,
- Maya Ghoussaini,
- Graham G. Giles,
- Rosalind Glasspool,
- Andrew K. Godwin,
- Mark S. Goldberg,
- David E. Goldgar,
- Anna González-Neira,
- Ellen L. Goode,
- Marc T. Goodman,
- Mark H. Greene,
- Jacek Gronwald,
- Pascal Guénel,
- Christopher A. Haiman,
- Per Hall,
- Emily Hallberg,
- Ute Hamann,
- Thomas V. O. Hansen,
- Patricia A. Harrington,
- Mikael Hartman,
- Norhashimah Hassan,
- Sue Healey,
- The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON),
- Florian Heitz,
- Josef Herzog,
- Estrid Høgdall,
- Claus K. Høgdall,
- Frans B. L. Hogervorst,
- Antoinette Hollestelle,
- John L. Hopper,
- Peter J. Hulick,
- Tomasz Huzarski,
- Evgeny N. Imyanitov,
- KConFab Investigators,
- Australian Ovarian Cancer Study Group,
- Claudine Isaacs,
- Hidemi Ito,
- Anna Jakubowska,
- Ramunas Janavicius,
- Allan Jensen,
- Esther M. John,
- Nichola Johnson,
- Maria Kabisch,
- Daehee Kang,
- Miroslav Kapuscinski,
- Beth Y. Karlan,
- Sofia Khan,
- Lambertus A. Kiemeney,
- Susanne Kruger Kjaer,
- Julia A. Knight,
- Irene Konstantopoulou,
- Veli-Matti Kosma,
- Vessela Kristensen,
- Jolanta Kupryjanczyk,
- Ava Kwong,
- Miguel de la Hoya,
- Yael Laitman,
- Diether Lambrechts,
- Nhu Le,
- Kim De Leeneer,
- Jenny Lester,
- Douglas A. Levine,
- Jingmei Li,
- Annika Lindblom,
- Jirong Long,
- Artitaya Lophatananon,
- Jennifer T. Loud,
- Karen Lu,
- Jan Lubinski,
- Arto Mannermaa,
- Siranoush Manoukian,
- Loic Le Marchand,
- Sara Margolin,
- Frederik Marme,
- Leon F. A. G. Massuger,
- Keitaro Matsuo,
- Sylvie Mazoyer,
- Lesley McGuffog,
- Catriona McLean,
- Iain McNeish,
- Alfons Meindl,
- Usha Menon,
- Arjen R. Mensenkamp,
- Roger L. Milne,
- Marco Montagna,
- Kirsten B. Moysich,
- Kenneth Muir,
- Anna Marie Mulligan,
- Katherine L. Nathanson,
- Roberta B. Ness,
- Susan L. Neuhausen,
- Heli Nevanlinna,
- Silje Nord,
- Robert L. Nussbaum,
- Kunle Odunsi,
- Kenneth Offit,
- Edith Olah,
- Olufunmilayo I. Olopade,
- Janet E. Olson,
- Curtis Olswold,
- David O’Malley,
- Irene Orlow,
- Nick Orr,
- Ana Osorio,
- Sue Kyung Park,
- Celeste L. Pearce,
- Tanja Pejovic,
- Paolo Peterlongo,
- Georg Pfeiler,
- Catherine M. Phelan,
- Elizabeth M. Poole,
- Katri Pylkäs,
- Paolo Radice,
- Johanna Rantala,
- Muhammad Usman Rashid,
- Gad Rennert,
- Valerie Rhenius,
- Kerstin Rhiem,
- Harvey A. Risch,
- Gus Rodriguez,
- Mary Anne Rossing,
- Anja Rudolph,
- Helga B. Salvesen,
- Suleeporn Sangrajrang,
- Elinor J. Sawyer,
- Joellen M. Schildkraut,
- Marjanka K. Schmidt,
- Rita K. Schmutzler,
- Thomas A. Sellers,
- Caroline Seynaeve,
- Mitul Shah,
- Chen-Yang Shen,
- Xiao-Ou Shu,
- Weiva Sieh,
- Christian F. Singer,
- Olga M. Sinilnikova,
- Susan Slager,
- Honglin Song,
- Penny Soucy,
- Melissa C. Southey,
- Marie Stenmark-Askmalm,
- Dominique Stoppa-Lyonnet,
- Christian Sutter,
- Anthony Swerdlow,
- Sandrine Tchatchou,
- Manuel R. Teixeira,
- Soo H. Teo,
- Kathryn L. Terry,
- Mary Beth Terry,
- Mads Thomassen,
- Maria Grazia Tibiletti,
- Laima Tihomirova,
- Silvia Tognazzo,
- Amanda Ewart Toland,
- Ian Tomlinson,
- Diana Torres,
- Thérèse Truong,
- Chiu-chen Tseng,
- Nadine Tung,
- Shelley S. Tworoger,
- Celine Vachon,
- Ans M. W. van den Ouweland,
- Helena C. van Doorn,
- Elizabeth J. van Rensburg,
- Laura J. Van't Veer,
- Adriaan Vanderstichele,
- Ignace Vergote,
- Joseph Vijai,
- Qin Wang,
- Shan Wang-Gohrke,
- Jeffrey N. Weitzel,
- Nicolas Wentzensen,
- Alice S. Whittemore,
- Hans Wildiers,
- Robert Winqvist,
- Anna H. Wu,
- Drakoulis Yannoukakos,
- Sook-Yee Yoon,
- Jyh-Cherng Yu,
- Wei Zheng,
- Ying Zheng,
- Kum Kum Khanna,
- Jacques Simard,
- Alvaro N. Monteiro,
- Juliet D. French,
- Fergus J. Couch,
- Matthew L. Freedman,
- Douglas F. Easton,
- Alison M. Dunning,
- Paul D. Pharoah,
- Stacey L. Edwards,
- Georgia Chenevix-Trench,
- Antonis C. Antoniou,
- Simon A. Gayther
Affiliations
- Kate Lawrenson
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
- Siddhartha Kar
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Karen McCue
- QIMR Berghofer Medical Research Institute
- Karoline Kuchenbaeker
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Kyriaki Michailidou
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Jonathan Tyrer
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Jonathan Beesley
- QIMR Berghofer Medical Research Institute
- Susan J. Ramus
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
- Qiyuan Li
- Medical College, Xiamen University
- Melissa K. Delgado
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
- Janet M. Lee
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
- Kristiina Aittomäki
- Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki
- Irene L. Andrulis
- Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
- Hoda Anton-Culver
- Department of Epidemiology, Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine
- Volker Arndt
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Banu K. Arun
- University of Texas MD Anderson Cancer Center
- Brita Arver
- Department of Oncology, Karolinska University Hospital
- Elisa V. Bandera
- Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey
- Monica Barile
- Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia
- Rosa B. Barkardottir
- Department of Pathology, Landspitali University Hospital and BMC (Biomedical Centre), Faculty of Medicine, University of Iceland
- Daniel Barrowdale
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Matthias W. Beckmann
- Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN
- Javier Benitez
- Human Cancer Genetics Program, Spanish National Cancer Research Centre
- Andrew Berchuck
- Department of Obstetrics and Gynecology, Duke University Medical Center
- Maria Bisogna
- Department of Surgery, Gynecology Service, Memorial Sloan-Kettering Cancer Center
- Line Bjorge
- Department of Gynecology and Obstetrics, Haukeland University Hospital
- Carl Blomqvist
- Department of Oncology, Helsinki University Hospital, University of Helsinki
- William Blot
- Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
- Natalia Bogdanova
- Gynaecology Research Unit, Hannover Medical School
- Anders Bojesen
- Department of Clinical Genetics, Vejle Hospital
- Stig E. Bojesen
- Faculty of Health and Medical Sciences, University of Copenhagen
- Manjeet K. Bolla
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Bernardo Bonanni
- Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia
- Anne-Lise Børresen-Dale
- Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet
- Hiltrud Brauch
- Dr Margarete Fischer-Bosch-Institute of Clinical Pharmacology
- Paul Brennan
- International Agency for Research on Cancer
- Hermann Brenner
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Fiona Bruinsma
- Cancer Epidemiology Centre, Cancer Council Victoria
- Joan Brunet
- Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology
- Shaik Ahmad Buhari
- Department of Surgery, National University Health System
- Barbara Burwinkel
- Molecular Epidemiology Group, German Cancer Research Center (DKFZ)
- Ralf Butzow
- Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital
- Saundra S. Buys
- Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine
- Qiuyin Cai
- Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
- Trinidad Caldes
- Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
- Ian Campbell
- Cancer Genetics Laboratory, Peter MacCallum Cancer Centre
- Rikki Canniotto
- Division of Cancer Prevention and Population Sciences, Cancer Pathology & Prevention, Roswell Park Cancer Institute
- Jenny Chang-Claude
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Jocelyne Chiquette
- Unité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Centre de recherche FRSQ du Centre hospitalier affilié universitaire de Québec
- Ji-Yeob Choi
- Cancer Research Institute, Seoul National University
- Kathleen B. M. Claes
- Center for Medical Genetics, Ghent University
- GEMO Study Collaborators
- Linda S. Cook
- Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico
- Angela Cox
- Department of Oncology, Sheffield Cancer Research, University of Sheffield
- Daniel W. Cramer
- Harvard HT Chan School of Public Health
- Simon S. Cross
- Department of Neuroscience, Academic Unit of Pathology, University of Sheffield
- Cezary Cybulski
- Department of Genetics and Pathology, Pomeranian Medical University
- Kamila Czene
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Mary B. Daly
- Department of Clinical Genetics, Fox Chase Cancer Center
- Francesca Damiola
- INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon
- Agnieszka Dansonka-Mieszkowska
- Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology
- Hatef Darabi
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Joe Dennis
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Peter Devilee
- Department of Pathology, Leiden University Medical Center
- Orland Diez
- Oncogenetics Group, University Hospital Vall d’Hebron, Vall d’Hebron Institute of Oncology (VHIO) and Universitat Autònoma de Barcelona
- Jennifer A. Doherty
- Department of Community and Family Medicine, Section of Biostatistics & Epidemiology, The Geisel School of Medicine at Dartmouth
- Susan M. Domchek
- Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
- Cecilia M. Dorfling
- Department of Genetics, University of Pretoria
- Thilo Dörk
- Gynaecology Research Unit, Hannover Medical School
- Martine Dumont
- Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University
- Hans Ehrencrona
- Department of Immunology, Genetics and Pathology, Uppsala University
- Bent Ejlertsen
- Department of Oncology, Rigshospitalet, Copenhagen University Hospital
- Steve Ellis
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge
- EMBRACE
- Christoph Engel
- Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
- Eunjung Lee
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
- D. Gareth Evans
- Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust
- Peter A. Fasching
- Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN
- Lidia Feliubadalo
- Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute),Catalan Institute of Oncology
- Jonine Figueroa
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Dieter Flesch-Janys
- Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf
- Olivia Fletcher
- Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research
- Henrik Flyger
- Department of Breast Surgery, Herlev Hospital, Copenhagen University Hospital
- Lenka Foretova
- Masaryk Memorial Cancer Institute and Medical Faculty MU
- Florentia Fostira
- Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis
- William D. Foulkes
- Departments of Human Genetics and Oncology, Program in Cancer Genetics, McGill University, Montreal
- Brooke L. Fridley
- Biostatistics and Informatics Shared Resource, University of Kansas Medical Center
- Eitan Friedman
- Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center
- Debra Frost
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Gaetana Gambino
- Department of Laboratory Medicine, Section of Genetic Oncology, University and University Hospital of Pisa
- Patricia A. Ganz
- Division of Cancer Prevention & Control Research, UCLA Schools of Medicine and Public Health, Jonsson Comprehensive Cancer Center
- Judy Garber
- Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute
- Montserrat García-Closas
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Aleksandra Gentry-Maharaj
- Women's Cancer, UCL EGA Institute for Women's Health
- Maya Ghoussaini
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Graham G. Giles
- Cancer Epidemiology Centre, Cancer Council Victoria
- Rosalind Glasspool
- Cancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre
- Andrew K. Godwin
- Department of Pathology and Laboratory Medicine, University of Kansas Medical Center
- Mark S. Goldberg
- Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University
- David E. Goldgar
- Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine
- Anna González-Neira
- Human Cancer Genetics Program, Spanish National Cancer Research Centre
- Ellen L. Goode
- Department of Health Sciences Research, Mayo Clinic
- Marc T. Goodman
- Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Mark H. Greene
- Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, National Institutes of Health
- Jacek Gronwald
- Department of Genetics and Pathology, Pomeranian Medical University
- Pascal Guénel
- Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM
- Christopher A. Haiman
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
- Per Hall
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Emily Hallberg
- Department of Health Sciences Research, Mayo Clinic
- Ute Hamann
- Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
- Thomas V. O. Hansen
- Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital
- Patricia A. Harrington
- Department of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory
- Mikael Hartman
- Department of Surgery, National University Health System
- Norhashimah Hassan
- Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre
- Sue Healey
- QIMR Berghofer Medical Research Institute
- The Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON)
- Florian Heitz
- Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte
- Josef Herzog
- Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network
- Estrid Høgdall
- Department of Pathology, Molecular Unit, Herlev Hospital, University of Copenhagen
- Claus K. Høgdall
- Department of Gynecology, Rigshospitalet, University of Copenhagen
- Frans B. L. Hogervorst
- Family Cancer Clinic, Netherlands Cancer Institute
- Antoinette Hollestelle
- Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute
- John L. Hopper
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
- Peter J. Hulick
- Center for Medical Genetics, NorthShore University Health System
- Tomasz Huzarski
- Department of Genetics and Pathology, Pomeranian Medical University
- Evgeny N. Imyanitov
- N.N. Petrov Institute of Oncology
- KConFab Investigators
- Australian Ovarian Cancer Study Group
- Claudine Isaacs
- Lombardi Comprehensive Cancer Center, Georgetown University
- Hidemi Ito
- Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
- Anna Jakubowska
- Department of Genetics and Pathology, Pomeranian Medical University
- Ramunas Janavicius
- State Research Institute Centre for Innovative Medicine
- Allan Jensen
- Department of Gynecology, Rigshospitalet, University of Copenhagen
- Esther M. John
- Department of Epidemiology, Cancer Prevention Institute of California
- Nichola Johnson
- Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research
- Maria Kabisch
- Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
- Daehee Kang
- Cancer Research Institute, Seoul National University
- Miroslav Kapuscinski
- Centre for Epidemiology and Biostatistics, University of Melbourne
- Beth Y. Karlan
- Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Sofia Khan
- Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital
- Lambertus A. Kiemeney
- Radboud University Medical Centre, Radboud Institute for Health Sciences
- Susanne Kruger Kjaer
- Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center
- Julia A. Knight
- Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
- Irene Konstantopoulou
- Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research ‘Demokritos’, Aghia Paraskevi Attikis
- Veli-Matti Kosma
- Department of Clinical Pathology, Imaging Center, Kuopio University Hospital
- Vessela Kristensen
- Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet
- Jolanta Kupryjanczyk
- Department of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology
- Ava Kwong
- The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital
- Miguel de la Hoya
- Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
- Yael Laitman
- Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center
- Diether Lambrechts
- Vesalius Research Center, VIB
- Nhu Le
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
- Kim De Leeneer
- Center for Medical Genetics, Ghent University
- Jenny Lester
- Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Douglas A. Levine
- Department of Surgery, Gynecology Service, Memorial Sloan-Kettering Cancer Center
- Jingmei Li
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Annika Lindblom
- Department of Molecular Medicine and Surgery, Karolinska Institutet
- Jirong Long
- Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
- Artitaya Lophatananon
- Division of Health Sciences, Warwick Medical School, Warwick University
- Jennifer T. Loud
- Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, National Institutes of Health
- Karen Lu
- Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center
- Jan Lubinski
- Department of Genetics and Pathology, Pomeranian Medical University
- Arto Mannermaa
- Department of Clinical Pathology, Imaging Center, Kuopio University Hospital
- Siranoush Manoukian
- Department of Preventive and Predictive Medicine, Unit of Medical Genetics, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT)
- Loic Le Marchand
- University of Hawaii Cancer Center
- Sara Margolin
- Department of Oncology - Pathology, Karolinska Institutet
- Frederik Marme
- Department of Obstetrics and Gynecology, University of Heidelberg
- Leon F. A. G. Massuger
- Department of Gynaecology, Radboud University Medical Centre
- Keitaro Matsuo
- Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences
- Sylvie Mazoyer
- INSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon
- Lesley McGuffog
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Catriona McLean
- Anatomical Pathology, The Alfred Hospital
- Iain McNeish
- Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research
- Alfons Meindl
- Division of Gynaecology and Obstetrics, Technische Universität München
- Usha Menon
- Women's Cancer, UCL EGA Institute for Women's Health
- Arjen R. Mensenkamp
- Department of Human Genetics, Radboud University Medical Centre
- Roger L. Milne
- Cancer Epidemiology Centre, Cancer Council Victoria
- Marco Montagna
- Immunology and Molecular Oncology Unit, Instituto Oncologico Veneto IOV, IRCCS
- Kirsten B. Moysich
- Department of Cancer Prevention and Control, Roswell Park Cancer Institute
- Kenneth Muir
- Division of Health Sciences, Warwick Medical School, Warwick University
- Anna Marie Mulligan
- Laboratory Medicine Program, University Health Network
- Katherine L. Nathanson
- Department of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania
- Roberta B. Ness
- The University of Texas School of Public Health
- Susan L. Neuhausen
- Department of Population Sciences, Beckman Research Institute of City of Hope
- Heli Nevanlinna
- Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital
- Silje Nord
- K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo
- Robert L. Nussbaum
- Department of Medicine and Genetics, University of California
- Kunle Odunsi
- Department of Gynecological Oncology, Roswell Park Cancer Institute
- Kenneth Offit
- Department of Medicine, Memorial Sloan-Kettering Cancer Center
- Edith Olah
- Department of Molecular Genetics, National Institute of Oncology
- Olufunmilayo I. Olopade
- Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center
- Janet E. Olson
- Department of Health Sciences Research, Mayo Clinic
- Curtis Olswold
- Department of Health Sciences Research, Mayo Clinic
- David O’Malley
- The Ohio State University and the James Cancer Center
- Irene Orlow
- Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center
- Nick Orr
- Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research
- Ana Osorio
- Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO)
- Sue Kyung Park
- Department of Biomedical Sciences, Seoul National University College of Medicine
- Celeste L. Pearce
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
- Tanja Pejovic
- Department of Obstetrics and Gynecology, Oregon Health and Science University
- Paolo Peterlongo
- IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology
- Georg Pfeiler
- Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna
- Catherine M. Phelan
- Department of Cancer Epidemiology, Moffitt Cancer Center
- Elizabeth M. Poole
- Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School
- Katri Pylkäs
- Laboratory of Cancer Genetics and Tumour Biology, Northern Finland Laboratory Centre NordLab
- Paolo Radice
- Department of Preventive and Predictive Medicine, Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT)
- Johanna Rantala
- Department of Clinical Genetics, Karolinska University Hospital
- Muhammad Usman Rashid
- Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
- Gad Rennert
- Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine
- Valerie Rhenius
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Kerstin Rhiem
- Department of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Centre of Familial Breast and Ovarian Cancer, Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne
- Harvey A. Risch
- Department of Chronic Disease Epidemiology, Yale School of Public Health
- Gus Rodriguez
- Division of Gynecologic Oncology, NorthShore University HealthSystem
- Mary Anne Rossing
- Division of Public Health Sciences, Program in Epidemiology, Fred Hutchinson Cancer Research Center
- Anja Rudolph
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Helga B. Salvesen
- Department of Gynecology and Obstetrics, Haukeland University Hospital
- Suleeporn Sangrajrang
- National Cancer Institute
- Elinor J. Sawyer
- Research Oncology, Guy’s Hospital, King's College London
- Joellen M. Schildkraut
- Department of Community and Family Medicine, Duke University Medical Center
- Marjanka K. Schmidt
- Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital
- Rita K. Schmutzler
- Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne
- Thomas A. Sellers
- Department of Cancer Epidemiology, Moffitt Cancer Center
- Caroline Seynaeve
- Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute
- Mitul Shah
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Chen-Yang Shen
- Taiwan Biobank, Institute of Biomedical Sciences, Academia Sinica
- Xiao-Ou Shu
- Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
- Weiva Sieh
- Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine
- Christian F. Singer
- Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna
- Olga M. Sinilnikova
- Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon – Centre Léon Bérard
- Susan Slager
- Department of Health Sciences Research, Mayo Clinic
- Honglin Song
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Penny Soucy
- Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University
- Melissa C. Southey
- Department of Pathology, University of Melbourne
- Marie Stenmark-Askmalm
- Department of Clinical Genetics, Lund University Hospital
- Dominique Stoppa-Lyonnet
- Institut Curie, Department of Tumour Biology, Paris, France; Department of Tumour Biology, Institut Curie, Paris, France
- Christian Sutter
- Department of Human Genetics, Institute of Human Genetics, University Hospital Heidelberg
- Anthony Swerdlow
- Division of Breast Cancer Research, The Institute of Cancer Research
- Sandrine Tchatchou
- Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital
- Manuel R. Teixeira
- Department of Genetics, Portuguese Oncology Institute
- Soo H. Teo
- Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre
- Kathryn L. Terry
- Harvard HT Chan School of Public Health
- Mary Beth Terry
- Department of Epidemiology, Mailman School of Public Health, Columbia University
- Mads Thomassen
- Department of Clinical Genetics, Odense University Hospital
- Maria Grazia Tibiletti
- UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria
- Laima Tihomirova
- Latvian Biomedical Research and Study Centre
- Silvia Tognazzo
- Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico)
- Amanda Ewart Toland
- Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University
- Ian Tomlinson
- Wellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford
- Diana Torres
- Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ)
- Thérèse Truong
- Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM
- Chiu-chen Tseng
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
- Nadine Tung
- Department of Medical Oncology, Beth Israel Deaconess Medical Center
- Shelley S. Tworoger
- Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School
- Celine Vachon
- Department of Health Sciences Research, Mayo Clinic
- Ans M. W. van den Ouweland
- Department of Clinical Genetics, Erasmus University Medical Center
- Helena C. van Doorn
- Department of Gynecology, Family Cancer Clinic, Erasmus MC Cancer Institute
- Elizabeth J. van Rensburg
- Department of Genetics, University of Pretoria
- Laura J. Van't Veer
- Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital
- Adriaan Vanderstichele
- Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven
- Ignace Vergote
- Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven
- Joseph Vijai
- Department of Medicine, Memorial Sloan-Kettering Cancer Center
- Qin Wang
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Shan Wang-Gohrke
- Jeffrey N. Weitzel
- Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network
- Nicolas Wentzensen
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Alice S. Whittemore
- Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine
- Hans Wildiers
- Department of General Medical Oncology, Multidisciplinary Breast Center, University Hospitals Leuven
- Robert Winqvist
- Laboratory of Cancer Genetics and Tumour Biology, Northern Finland Laboratory Centre NordLab
- Anna H. Wu
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
- Drakoulis Yannoukakos
- Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research ‘Demokritos’
- Sook-Yee Yoon
- Cancer Research Initiatives Foundation, Sime Darby Medical Centre
- Jyh-Cherng Yu
- Department of Surgery, Tri-Service General Hospital, National Defense Medical Center
- Wei Zheng
- Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
- Ying Zheng
- Shanghai Center for Disease Control and Prevention
- Kum Kum Khanna
- QIMR Berghofer Medical Research Institute
- Jacques Simard
- Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University
- Alvaro N. Monteiro
- Division of Population Sciences, Cancer Epidemiology Program, H. Lee Moffitt Cancer Center & Research Institute
- Juliet D. French
- QIMR Berghofer Medical Research Institute
- Fergus J. Couch
- Department of Health Sciences Research, Mayo Clinic
- Matthew L. Freedman
- Department of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute
- Douglas F. Easton
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Alison M. Dunning
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Paul D. Pharoah
- Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Stacey L. Edwards
- QIMR Berghofer Medical Research Institute
- Georgia Chenevix-Trench
- QIMR Berghofer Medical Research Institute
- Antonis C. Antoniou
- Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge
- Simon A. Gayther
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center
- DOI
- https://doi.org/10.1038/ncomms12675
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 22
Abstract
A region on chromosome 19p13 is associated with the risk of developing ovarian and breast cancer. Here, the authors genotyped SNPs in this region in thousands of breast and ovarian cancer patients and identified SNPs associated with three genes, which were analysed with functional studies.
