The protein phosphatase 2A holoenzyme is a key regulator of starch metabolism and bradyzoite differentiation in Toxoplasma gondii

Jin-Lei Wang; Ting-Ting Li; Hany M. Elsheikha; Qin-Li Liang; Zhi-Wei Zhang; Meng Wang; L. David Sibley; Xing-Quan Zhu

doi:10.1038/s41467-022-35267-5

Nature Communications (Dec 2022)

The protein phosphatase 2A holoenzyme is a key regulator of starch metabolism and bradyzoite differentiation in Toxoplasma gondii

Jin-Lei Wang,
Ting-Ting Li,
Hany M. Elsheikha,
Qin-Li Liang,
Zhi-Wei Zhang,
Meng Wang,
L. David Sibley,
Xing-Quan Zhu

Affiliations

Jin-Lei Wang: State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences
Ting-Ting Li: State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences
Hany M. Elsheikha: Faculty of Medicine and Health Sciences, School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus
Qin-Li Liang: State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences
Zhi-Wei Zhang: State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences
Meng Wang: State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences
L. David Sibley: Department of Molecular Microbiology, Washington University School of Medicine in St. Louis
Xing-Quan Zhu: Laboratory of Parasitic Diseases, College of Veterinary Medicine, Shanxi Agricultural University

DOI: https://doi.org/10.1038/s41467-022-35267-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Protein phosphorylation and dephosphorylation are essential aspects of biology. Wang et al., report that Toxoplasma gondiiprotein phosphatase 2A (PP2A) mediated dephosphorylation is critical for starch metabolism and bradyzoite differentiation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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