p16(INK4A) expression in invasive laryngeal cancer

Brenda Y. Hernandez; Mobeen Rahman; Charles F. Lynch; Wendy Cozen; Elizabeth R. Unger; Martin Steinau; Trevor Thompson; Maria Sibug Saber; Sean F. Altekruse; Marc T. Goodman; Amy Powers; Christopher Lyu; Mona Saraiya

Papillomavirus Research (Dec 2016)

p16(INK4A) expression in invasive laryngeal cancer

Brenda Y. Hernandez,
Mobeen Rahman,
Charles F. Lynch,
Wendy Cozen,
Elizabeth R. Unger,
Martin Steinau,
Trevor Thompson,
Maria Sibug Saber,
Sean F. Altekruse,
Marc T. Goodman,
Amy Powers,
Christopher Lyu,
Mona Saraiya

Affiliations

Brenda Y. Hernandez: University of Hawaii Cancer Center, 701 Ilalo Street #239, Honolulu, HI 96813, USA; Corresponding author.
Mobeen Rahman: University of Hawaii John A. Burns School of Medicine, 651 Ilalo Street #411E, Honolulu, HI 96813, USA
Charles F. Lynch: The University of Iowa, College of Public Health, Department of Epidemiology, 145 North Riverside Drive S447 CPHB, Iowa City, IA 52242-2007, USA
Wendy Cozen: University of Southern California, Norris Comprehensive Cancer Center and Keck School of Medicine, Departments of Preventive Medicine and Pathology, 1441 Eastlake Avenue MC 9175, Los Angeles, CA 90089-9175, USA
Elizabeth R. Unger: Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Atlanta, GA 30329-4027, USA
Martin Steinau: Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Division of High-Consequence Pathogens and Pathology, Atlanta, GA 30329-4027, USA
Trevor Thompson: Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop F-76, Atlanta, GA 30341-3717, USA
Maria Sibug Saber: University of Southern California, Norris Comprehensive Cancer Center, 1441 Eastlake Avenue #4420, Los Angeles, CA 90089-9175, USA
Sean F. Altekruse: National Cancer Institute, Surveillance Research Program, 9609 Medical Center Drive, Room 4E536, Rockville, MD 20850, USA
Marc T. Goodman: Cedars-Sinai Medical Center, 8700 Beverly Blvd, Room 1S37, Los Angeles, CA 90048, USA
Amy Powers: The Queen׳s Medical Center, Department of Pathology, 1301 Punchbowl St., Iolani 4, Honolulu, HI 96813, USA
Christopher Lyu: Battelle, 100 Capitola Drive, Suite 200, Durham, NC 27713, USA
Mona Saraiya: Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341-3717, USA

Journal volume & issue: Vol. 2
pp. 52 – 55

Abstract

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We examined p16 expression in tumors from a population-based sample of laryngeal cancer cases diagnosed in the U.S. Samples had been previously genotyped for HPV DNA.Overall, p16 expression was observed in laryngeal tissue from 8 of 101 (7.9%) cases. p16 expression was observed in 2 of 16 (12.5%) cases previously determined to be HPV DNA positive. The two cases dually positive for p16 and HPV DNA were non-keratinizing SCC and papillary SCC tumors that were positive for genotypes 18 and 35/89, respectively. Positivity for p16 and/or HPV DNA was not associated with 5-year survival (log-rank p value=0.55). Our findings support a limited role of HPV in laryngeal carcinogenesis. p16 is not a reliable surrogate for HPV status in laryngeal cancers and is not a predictor of laryngeal cancer survival. Keywords: Larynx, Laryngeal cancer, Human papillomavirus, HPV, P16(INK4A), P16

Published in Papillomavirus Research

ISSN: 2405-8521 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: https://www.journals.elsevier.com/papillomavirus-research/

About the journal