The Implication of Sphingolipids in Viral Infections

Sanya Thomas; Stephen Varghese Samuel; Annmarie Hoch; Caitlin Syphurs; Joann Diray-Arce

doi:10.3390/ijms242417303

International Journal of Molecular Sciences (Dec 2023)

The Implication of Sphingolipids in Viral Infections

Sanya Thomas,
Stephen Varghese Samuel,
Annmarie Hoch,
Caitlin Syphurs,
Joann Diray-Arce

Affiliations

Sanya Thomas: Precision Vaccines Program, Department of Pediatrics, Boston Children’s Hospital, Boston, MA 02115, USA
Stephen Varghese Samuel: Harvard Medical School, Boston, MA 02115, USA
Annmarie Hoch: Precision Vaccines Program, Department of Pediatrics, Boston Children’s Hospital, Boston, MA 02115, USA
Caitlin Syphurs: Precision Vaccines Program, Department of Pediatrics, Boston Children’s Hospital, Boston, MA 02115, USA
Joann Diray-Arce: Precision Vaccines Program, Department of Pediatrics, Boston Children’s Hospital, Boston, MA 02115, USA

DOI: https://doi.org/10.3390/ijms242417303
Journal volume & issue: Vol. 24, no. 24
p. 17303

Abstract

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Sphingolipids are involved in cell signaling and metabolic pathways, and their metabolites play a critical role in host defense against intracellular pathogens. Here, we review the known mechanisms of sphingolipids in viral infections and discuss the potential implication of the study of sphingolipid metabolism in vaccine and therapeutic development.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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