Shifting the optimal stiffness for cell migration

Benjamin L. Bangasser; Ghaidan A. Shamsan; Clarence E. Chan; Kwaku N. Opoku; Erkan Tüzel; Benjamin W. Schlichtmann; Jesse A. Kasim; Benjamin J. Fuller; Brannon R. McCullough; Steven S. Rosenfeld; David J. Odde

doi:10.1038/ncomms15313

Nature Communications (May 2017)

Shifting the optimal stiffness for cell migration

Benjamin L. Bangasser,
Ghaidan A. Shamsan,
Clarence E. Chan,
Kwaku N. Opoku,
Erkan Tüzel,
Benjamin W. Schlichtmann,
Jesse A. Kasim,
Benjamin J. Fuller,
Brannon R. McCullough,
Steven S. Rosenfeld,
David J. Odde

Affiliations

Benjamin L. Bangasser: Department of Biomedical Engineering, University of Minnesota
Ghaidan A. Shamsan: Department of Biomedical Engineering, University of Minnesota
Clarence E. Chan: Department of Biomedical Engineering, University of Minnesota
Kwaku N. Opoku: Department of Biomedical Engineering, University of Minnesota
Erkan Tüzel: Department of Biomedical Engineering, University of Minnesota
Benjamin W. Schlichtmann: Department of Biomedical Engineering, University of Minnesota
Jesse A. Kasim: Department of Biomedical Engineering, University of Minnesota
Benjamin J. Fuller: Department of Biomedical Engineering, University of Minnesota
Brannon R. McCullough: Department of Biomedical Engineering, University of Minnesota
Steven S. Rosenfeld: Brain Tumor and Neuro-Oncology Center, Cleveland Clinic
David J. Odde: Department of Biomedical Engineering, University of Minnesota

DOI: https://doi.org/10.1038/ncomms15313
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Cell migration is sensitive to environmental stiffness, but how cells sense optimal stiffness is not known. Here the authors develop a model that predicts that the optimum can be shifted by altering the number of active molecular motors and clutches, and verify their model in two cell types.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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